Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 516392..516987 Replicon chromosome
Accession NC_010801
Organism Burkholderia multivorans ATCC 17616

Toxin (Protein)


Gene name chpB Uniprot ID A0A2A4C4A8
Locus tag BMULJ_RS29090 Protein ID WP_012218081.1
Coordinates 516637..516987 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A2A4C1X6
Locus tag BMULJ_RS29085 Protein ID WP_012218082.1
Coordinates 516392..516643 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMULJ_RS29055 512341..512847 - 507 WP_012218086.1 arsenate reductase (azurin) small subunit -
BMULJ_RS29065 513740..513934 + 195 WP_012464904.1 hypothetical protein -
BMULJ_RS29070 514107..514898 - 792 WP_012218085.1 SOS response-associated peptidase family protein -
BMULJ_RS29075 515029..515355 - 327 WP_012464905.1 H-NS histone family protein -
BMULJ_RS29080 515520..516200 + 681 WP_012218083.1 site-specific integrase -
BMULJ_RS29085 516392..516643 + 252 WP_012218082.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BMULJ_RS29090 516637..516987 + 351 WP_012218081.1 type II toxin-antitoxin system ChpB family toxin Toxin
BMULJ_RS29095 516998..517510 + 513 WP_012218080.1 hypothetical protein -
BMULJ_RS29100 517573..517758 + 186 WP_038442441.1 hypothetical protein -
BMULJ_RS34845 517755..517916 - 162 WP_155295622.1 hypothetical protein -
BMULJ_RS34850 518001..518333 + 333 WP_096508413.1 hypothetical protein -
BMULJ_RS34855 518357..518926 + 570 WP_012218078.1 hypothetical protein -
BMULJ_RS33990 519140..520084 + 945 WP_012218077.1 hypothetical protein -
BMULJ_RS29105 520140..520394 + 255 WP_038442290.1 hypothetical protein -
BMULJ_RS34860 520404..520847 + 444 WP_143331194.1 hypothetical protein -
BMULJ_RS29110 520866..521225 + 360 WP_012218076.1 hypothetical protein -
BMULJ_RS29115 521243..521452 + 210 WP_038442273.1 hypothetical protein -
BMULJ_RS33995 521473..521862 + 390 WP_080512399.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-115)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12420.35 Da        Isoelectric Point: 8.9716

>T22900 WP_012218081.1 NC_010801:516637-516987 [Burkholderia multivorans ATCC 17616]
MVKRVKFDRGDIVRVSLNRTIGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGSGTETQGVALV
NMVRMLDLEARGARTIERAPAEVVEDALARLQSIIE

Download         Length: 351 bp

>T22900 NC_010801:516637-516987 [Burkholderia multivorans ATCC 17616]
ATGGTAAAGCGGGTCAAGTTCGATCGGGGCGACATCGTGCGCGTTAGCCTGAACCGGACCATCGGGCGCGAGCAGCAGGG
CGATTTCCGTCCCGCGCTTGTGCTGTCTCCCGCCGCATTCAATGCCTTGGGGGTGGCGCTCGTCGCGCCGATCACGCAGG
GCGGGGAGTTTGCGCGCTTCGCAGGATTCGCCGTGCCGCTCTCTGGCTCGGGCACCGAGACGCAGGGCGTGGCCTTGGTG
AACATGGTCCGGATGCTCGATCTGGAGGCGCGTGGCGCACGGACGATCGAGCGGGCTCCGGCCGAGGTGGTCGAAGATGC
GCTGGCTCGGCTGCAATCGATAATCGAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8997.39 Da        Isoelectric Point: 6.9770

>AT22900 WP_012218082.1 NC_010801:516392-516643 [Burkholderia multivorans ATCC 17616]
MELKIQKWGNSAAVRLPAVLLEQMHASVGGSLNADVRPDGVLLTPARRKYALDELVAQCDAKAPFPADMAAWGEVRPVGR
EGW

Download         Length: 252 bp

>AT22900 NC_010801:516392-516643 [Burkholderia multivorans ATCC 17616]
ATGGAACTAAAAATTCAGAAATGGGGCAACAGTGCGGCGGTGCGACTCCCCGCCGTGTTGCTCGAGCAGATGCACGCCTC
GGTCGGCGGCTCGCTGAACGCCGACGTGCGTCCGGACGGCGTATTGCTGACCCCCGCGCGCCGCAAGTATGCGCTGGACG
AACTGGTCGCTCAGTGTGATGCGAAAGCGCCTTTCCCGGCGGACATGGCTGCATGGGGTGAGGTCAGGCCGGTAGGGCGT
GAAGGATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4C4A8

Antitoxin

Source ID Structure
AlphaFold DB A0A2A4C1X6

References