Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2218578..2219122 | Replicon | chromosome |
| Accession | NZ_CP089777 | ||
| Organism | Mycobacterium tuberculosis strain I0003270-1 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | LVJ72_RS10380 | Protein ID | WP_003409896.1 |
| Coordinates | 2218578..2218874 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | LVJ72_RS10385 | Protein ID | WP_003409899.1 |
| Coordinates | 2218871..2219122 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ72_RS10325 (LVJ72_10335) | 2213611..2213961 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| LVJ72_RS10330 (LVJ72_10340) | 2213972..2214874 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| LVJ72_RS10335 (LVJ72_10345) | 2214895..2215086 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| LVJ72_RS10340 (LVJ72_10350) | 2215087..2215383 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| LVJ72_RS10345 (LVJ72_10355) | 2215623..2215838 | + | 216 | WP_003409878.1 | antitoxin | - |
| LVJ72_RS10350 (LVJ72_10360) | 2215835..2216146 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ72_RS10355 (LVJ72_10365) | 2216120..2216641 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| LVJ72_RS10360 (LVJ72_10370) | 2216616..2216993 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| LVJ72_RS10365 (LVJ72_10375) | 2217035..2217484 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| LVJ72_RS10370 (LVJ72_10380) | 2217481..2218026 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| LVJ72_RS10375 (LVJ72_10385) | 2217915..2218529 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| LVJ72_RS10380 (LVJ72_10390) | 2218578..2218874 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LVJ72_RS10385 (LVJ72_10395) | 2218871..2219122 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| LVJ72_RS10390 (LVJ72_10400) | 2219109..2219603 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| LVJ72_RS10395 (LVJ72_10405) | 2219763..2220170 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ72_RS10400 (LVJ72_10410) | 2220174..2220446 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LVJ72_RS10405 (LVJ72_10415) | 2220479..2221699 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| LVJ72_RS10410 (LVJ72_10420) | 2222598..2223395 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T228995 WP_003409896.1 NZ_CP089777:c2218874-2218578 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T228995 NZ_CP124367:3314076-3314249 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT228995 WP_003409899.1 NZ_CP089777:c2219122-2218871 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT228995 NZ_CP124367:3313752-3314048 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |