Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1971527..1971987 Replicon chromosome
Accession NZ_CP089777
Organism Mycobacterium tuberculosis strain I0003270-1

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag LVJ72_RS09235 Protein ID WP_003898996.1
Coordinates 1971739..1971987 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag LVJ72_RS09230 Protein ID WP_003408528.1
Coordinates 1971527..1971739 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ72_RS09215 (LVJ72_09220) 1968005..1969192 - 1188 WP_003898992.1 nitrate transporter NarK -
LVJ72_RS09220 (LVJ72_09225) 1969479..1969763 + 285 WP_003408522.1 DUF1876 domain-containing protein -
LVJ72_RS09225 (LVJ72_09230) 1969777..1971459 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
LVJ72_RS09230 (LVJ72_09235) 1971527..1971739 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ72_RS09235 (LVJ72_09240) 1971739..1971987 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ72_RS09240 (LVJ72_09245) 1971995..1972732 + 738 WP_003898997.1 hypothetical protein -
LVJ72_RS09245 (LVJ72_09250) 1972826..1974526 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
LVJ72_RS09250 (LVJ72_09255) 1974811..1975212 - 402 WP_003408538.1 hypothetical protein -
LVJ72_RS09255 (LVJ72_09260) 1975202..1975813 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T228992 WP_003898996.1 NZ_CP089777:1971739-1971987 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T228992 NZ_CP124367:c2535071-2534964 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT228992 WP_003408528.1 NZ_CP089777:1971527-1971739 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT228992 NZ_CP124367:2535120-2535185 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References