Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1950795..1951408 Replicon chromosome
Accession NZ_CP089777
Organism Mycobacterium tuberculosis strain I0003270-1

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag LVJ72_RS09125 Protein ID WP_003408465.1
Coordinates 1950795..1951184 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag LVJ72_RS09130 Protein ID WP_003408469.1
Coordinates 1951181..1951408 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ72_RS09090 (LVJ72_09095) 1946424..1947338 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
LVJ72_RS09095 (LVJ72_09100) 1947341..1948171 + 831 WP_003916363.1 cyclase family protein -
LVJ72_RS09100 (LVJ72_09105) 1948171..1948521 + 351 WP_003898986.1 cupin domain-containing protein -
LVJ72_RS09105 (LVJ72_09110) 1948574..1949392 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
LVJ72_RS09110 (LVJ72_09115) 1949406..1950185 + 780 WP_003408460.1 IclR family transcriptional regulator -
LVJ72_RS09120 (LVJ72_09125) 1950616..1950747 + 132 Protein_1799 IS3 family transposase -
LVJ72_RS09125 (LVJ72_09130) 1950795..1951184 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ72_RS09130 (LVJ72_09135) 1951181..1951408 - 228 WP_003408469.1 antitoxin Antitoxin
LVJ72_RS09135 (LVJ72_09140) 1951626..1953110 + 1485 WP_003408473.1 biotin carboxylase -
LVJ72_RS09140 (LVJ72_09145) 1953107..1954354 + 1248 WP_003408476.1 serine hydrolase -
LVJ72_RS09145 (LVJ72_09150) 1954397..1954816 - 420 WP_003408483.1 hypothetical protein -
LVJ72_RS09150 (LVJ72_09155) 1954806..1955516 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T228991 WP_003408465.1 NZ_CP089777:c1951184-1950795 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T228991 NZ_CP124367:c2534588-2534481 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT228991 WP_003408469.1 NZ_CP089777:c1951408-1951181 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT228991 NZ_CP124367:2534645-2534702 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References