Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1018512..1019131 Replicon chromosome
Accession NZ_CP089777
Organism Mycobacterium tuberculosis strain I0003270-1

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag LVJ72_RS04825 Protein ID WP_003404726.1
Coordinates 1018697..1019131 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag LVJ72_RS04820 Protein ID WP_003898641.1
Coordinates 1018512..1018691 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ72_RS04805 (LVJ72_04800) 1013986..1015565 + 1580 Protein_947 serine hydrolase -
LVJ72_RS04810 (LVJ72_04805) 1015562..1017955 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
LVJ72_RS04815 (LVJ72_04810) 1018228..1018386 + 159 WP_003404720.1 hypothetical protein -
LVJ72_RS04820 (LVJ72_04815) 1018512..1018691 + 180 WP_003898641.1 antitoxin Antitoxin
LVJ72_RS04825 (LVJ72_04820) 1018697..1019131 + 435 WP_003404726.1 SRPBCC family protein Toxin
LVJ72_RS04830 (LVJ72_04825) 1019229..1020002 + 774 WP_031663918.1 VOC family protein -
LVJ72_RS04835 (LVJ72_04830) 1020067..1020516 + 450 WP_003404738.1 hypothetical protein -
LVJ72_RS04840 (LVJ72_04835) 1020651..1020881 - 231 WP_003898642.1 hypothetical protein -
LVJ72_RS04845 (LVJ72_04840) 1021048..1022556 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
LVJ72_RS04850 (LVJ72_04845) 1022558..1023796 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T228981 WP_003404726.1 NZ_CP089777:1018697-1019131 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T228981 NZ_CP124367:c516654-516552 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT228981 WP_003898641.1 NZ_CP089777:1018512-1018691 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT228981 NZ_CP124367:516514-516782 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References