Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | unclassified/Polyketide_cyc2(toxin) |
Location | 1018512..1019131 | Replicon | chromosome |
Accession | NZ_CP089777 | ||
Organism | Mycobacterium tuberculosis strain I0003270-1 |
Toxin (Protein)
Gene name | novel[antitoxin] | Uniprot ID | - |
Locus tag | LVJ72_RS04825 | Protein ID | WP_003404726.1 |
Coordinates | 1018697..1019131 (+) | Length | 145 a.a. |
Antitoxin (Protein)
Gene name | novel[toxin] | Uniprot ID | P9WJ06 |
Locus tag | LVJ72_RS04820 | Protein ID | WP_003898641.1 |
Coordinates | 1018512..1018691 (+) | Length | 60 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LVJ72_RS04805 (LVJ72_04800) | 1013986..1015565 | + | 1580 | Protein_947 | serine hydrolase | - |
LVJ72_RS04810 (LVJ72_04805) | 1015562..1017955 | + | 2394 | WP_003898639.1 | cation-translocating P-type ATPase | - |
LVJ72_RS04815 (LVJ72_04810) | 1018228..1018386 | + | 159 | WP_003404720.1 | hypothetical protein | - |
LVJ72_RS04820 (LVJ72_04815) | 1018512..1018691 | + | 180 | WP_003898641.1 | antitoxin | Antitoxin |
LVJ72_RS04825 (LVJ72_04820) | 1018697..1019131 | + | 435 | WP_003404726.1 | SRPBCC family protein | Toxin |
LVJ72_RS04830 (LVJ72_04825) | 1019229..1020002 | + | 774 | WP_031663918.1 | VOC family protein | - |
LVJ72_RS04835 (LVJ72_04830) | 1020067..1020516 | + | 450 | WP_003404738.1 | hypothetical protein | - |
LVJ72_RS04840 (LVJ72_04835) | 1020651..1020881 | - | 231 | WP_003898642.1 | hypothetical protein | - |
LVJ72_RS04845 (LVJ72_04840) | 1021048..1022556 | - | 1509 | WP_003404742.1 | carotenoid oxygenase family protein | - |
LVJ72_RS04850 (LVJ72_04845) | 1022558..1023796 | - | 1239 | WP_003404744.1 | acetyl-CoA acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 145 a.a. Molecular weight: 15754.47 Da Isoelectric Point: 9.7977
>T228981 WP_003404726.1 NZ_CP089777:1018697-1019131 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG
Download Length: 435 bp
>T228981 NZ_CP124367:c516654-516552 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 60 a.a. Molecular weight: 6403.07 Da Isoelectric Point: 4.5393
>AT228981 WP_003898641.1 NZ_CP089777:1018512-1018691 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS
Download Length: 180 bp
>AT228981 NZ_CP124367:516514-516782 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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