Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 760492..761180 Replicon chromosome
Accession NZ_CP089777
Organism Mycobacterium tuberculosis strain I0003270-1

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag LVJ72_RS03505 Protein ID WP_003403386.1
Coordinates 760492..760929 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag LVJ72_RS03510 Protein ID WP_003911263.1
Coordinates 760926..761180 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ72_RS03475 (LVJ72_03470) 756743..757753 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
LVJ72_RS03480 (LVJ72_03475) 758141..758524 - 384 WP_003403365.1 ribonuclease VapC6 -
LVJ72_RS03485 (LVJ72_03480) 758619..758774 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
LVJ72_RS03490 (LVJ72_03485) 758850..759566 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
LVJ72_RS03495 (LVJ72_03490) 759842..760150 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
LVJ72_RS03500 (LVJ72_03495) 760137..760382 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
LVJ72_RS03505 (LVJ72_03500) 760492..760929 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ72_RS03510 (LVJ72_03505) 760926..761180 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
LVJ72_RS03515 (LVJ72_03510) 761294..763657 + 2364 WP_003898547.1 arylsulfatase AtsD -
LVJ72_RS03520 (LVJ72_03515) 763720..764046 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LVJ72_RS03525 (LVJ72_03520) 763958..764296 + 339 WP_003403405.1 PIN domain-containing protein -
LVJ72_RS03530 (LVJ72_03525) 764293..764466 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T228979 WP_003403386.1 NZ_CP089777:c760929-760492 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T228979 NZ_CP124359:c4549038-4548865 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT228979 WP_003911263.1 NZ_CP089777:c761180-760926 [Mycobacterium tuberculosis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT228979 NZ_CP124359:c4549362-4549066 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCCGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References