Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 758141..758774 Replicon chromosome
Accession NZ_CP089777
Organism Mycobacterium tuberculosis strain I0003270-1

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag LVJ72_RS03480 Protein ID WP_003403365.1
Coordinates 758141..758524 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag LVJ72_RS03485 Protein ID WP_003403368.1
Coordinates 758619..758774 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ72_RS03455 (LVJ72_03450) 753433..753969 + 537 WP_003403341.1 50S ribosomal protein L10 -
LVJ72_RS03460 (LVJ72_03455) 754006..754398 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
LVJ72_RS03465 (LVJ72_03460) 754391..755086 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
LVJ72_RS03470 (LVJ72_03465) 755157..756662 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
LVJ72_RS03475 (LVJ72_03470) 756743..757753 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
LVJ72_RS03480 (LVJ72_03475) 758141..758524 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
LVJ72_RS03485 (LVJ72_03480) 758619..758774 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ72_RS03490 (LVJ72_03485) 758850..759566 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
LVJ72_RS03495 (LVJ72_03490) 759842..760150 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
LVJ72_RS03500 (LVJ72_03495) 760137..760382 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
LVJ72_RS03505 (LVJ72_03500) 760492..760929 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
LVJ72_RS03510 (LVJ72_03505) 760926..761180 - 255 WP_003911263.1 antitoxin VapB7 -
LVJ72_RS03515 (LVJ72_03510) 761294..763657 + 2364 WP_003898547.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T228976 WP_003403365.1 NZ_CP089777:c758524-758141 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T228976 NZ_CP124359:c4154720-4154433 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT228976 WP_003403368.1 NZ_CP089777:c758774-758619 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT228976 NZ_CP124359:c4154446-4154144 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References