Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 707867..708510 Replicon chromosome
Accession NZ_CP089777
Organism Mycobacterium tuberculosis strain I0003270-1

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag LVJ72_RS03210 Protein ID WP_003403187.1
Coordinates 708109..708510 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag LVJ72_RS03205 Protein ID WP_003403184.1
Coordinates 707867..708112 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ72_RS03170 (LVJ72_03165) 703147..703677 - 531 WP_003917320.1 two component system sensor kinase HK2 -
LVJ72_RS03175 (LVJ72_03170) 703661..704356 - 696 WP_003918099.1 two-component system response regulator TcrA -
LVJ72_RS03180 (LVJ72_03175) 704479..704790 + 312 WP_003403164.1 hypothetical protein -
LVJ72_RS03185 (LVJ72_03180) 704862..705812 + 951 WP_003900184.1 DUF1259 domain-containing protein -
LVJ72_RS03190 (LVJ72_03185) 706053..706637 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
LVJ72_RS03195 (LVJ72_03190) 706639..707349 + 711 Protein_633 IS607 family element RNA-guided endonuclease TnpB -
LVJ72_RS03200 (LVJ72_03195) 707352..707822 + 471 WP_003898523.1 hypothetical protein -
LVJ72_RS03205 (LVJ72_03200) 707867..708112 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ72_RS03210 (LVJ72_03205) 708109..708510 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ72_RS03215 (LVJ72_03210) 708501..708680 + 180 Protein_637 hypothetical protein -
LVJ72_RS03220 (LVJ72_03215) 709098..709295 - 198 WP_003403191.1 hypothetical protein -
LVJ72_RS03225 (LVJ72_03220) 709375..710532 - 1158 WP_003898524.1 hypothetical protein -
LVJ72_RS03230 (LVJ72_03225) 710584..710805 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LVJ72_RS03235 (LVJ72_03230) 710947..711552 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T228972 WP_003403187.1 NZ_CP089777:708109-708510 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T228972 NZ_CP124359:c3602568-3602266 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT228972 WP_003403184.1 NZ_CP089777:707867-708112 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT228972 NZ_CP124359:c3602230-3601889 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References