Detailed information of TA system TA022897

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 5505324..5505860
• Replicon: chromosome
• Accession: NC_010725
• Organism: Methylobacterium populi BJ001

Toxin (Protein)

• Gene name: parE
• Uniprot ID: B1Z8T2
• Locus tag: MPOP_RS25420
• Protein ID: WP_012456830.1
• Coordinates: 5505324..5505614 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: B1Z8T3
• Locus tag: MPOP_RS25425
• Protein ID: WP_012456831.1
• Coordinates: 5505615..5505860 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPOP_RS28575	5501204..5501857	-	654	Protein_5109	zinc ribbon domain-containing protein	-
MPOP_RS25405	5502306..5502563	-	258	WP_012456826.1	hypothetical protein	-
MPOP_RS25410	5502917..5503198	+	282	WP_012456827.1	hypothetical protein	-
MPOP_RS28580	5503195..5503371	+	177	WP_012456828.1	hypothetical protein	-
MPOP_RS28585	5503390..5503632	+	243	WP_012456829.1	hypothetical protein	-
MPOP_RS25415	5503649..5503990	+	342	WP_158022309.1	hypothetical protein	-
MPOP_RS28590	5504176..5504709	+	534	WP_131801257.1	hypothetical protein	-
MPOP_RS28595	5504703..5505305	+	603	WP_131801258.1	hypothetical protein	-
MPOP_RS25420	5505324..5505614	-	291	WP_012456830.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MPOP_RS25425	5505615..5505860	-	246	WP_012456831.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
MPOP_RS25430	5505991..5506257	+	267	WP_012456832.1	hypothetical protein	-
MPOP_RS28010	5506987..5507412	-	426	WP_162091593.1	Mov34/MPN/PAD-1 family protein	-
MPOP_RS28015	5507451..5509112	-	1662	WP_012456834.1	ThiF family adenylyltransferase	-
MPOP_RS28020	5509112..5510293	-	1182	WP_012456835.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10990.67 Da
• Isoelectric Point: 10.5720

>T22897 WP_012456830.1 NC_010725:c5505614-5505324 [Methylorubrum populi BJ001]
VKVRLSAAARRDLSGIWTYSAKRWDEAQADRYVRLFADSFDGLGRGIVKGRKADDVRPGYFKLAVGSHLIFYRMGAADVI
EVVRILHQRMDIDRHL

Nucleotide

• Length: 291 bp

>T22897 NC_010725:c5505614-5505324 [Methylorubrum populi BJ001]
GTGAAGGTCCGCCTCTCCGCCGCGGCGCGCCGAGACCTTTCCGGCATCTGGACCTATTCGGCGAAGCGCTGGGATGAGGC
TCAGGCTGATCGCTATGTGCGGCTGTTTGCCGATAGCTTCGACGGGCTCGGCCGCGGCATCGTCAAAGGCCGCAAAGCCG
ATGACGTCCGCCCTGGCTATTTCAAGCTCGCCGTCGGCTCGCACCTCATTTTTTATCGGATGGGCGCAGCCGATGTGATT
GAGGTCGTCCGAATCCTGCATCAGCGTATGGATATCGACCGGCATCTATAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8793.63 Da
• Isoelectric Point: 4.2813

>AT22897 WP_012456831.1 NC_010725:c5505860-5505615 [Methylorubrum populi BJ001]
MARNTSISLGDHFAQFIDSQVQGGRYGSASDVVRAGLRLLEEREAKLEALRSALDEGEASGDFQEFDADTFLASMRQPAG
Q

Nucleotide

• Length: 246 bp

>AT22897 NC_010725:c5505860-5505615 [Methylorubrum populi BJ001]
ATGGCCCGCAACACGTCGATCTCGCTCGGGGATCATTTCGCGCAGTTCATCGATAGCCAGGTCCAAGGCGGTCGCTATGG
CTCGGCCAGCGACGTGGTCCGGGCCGGTTTGCGCCTCCTCGAAGAGCGCGAAGCCAAGCTTGAAGCGCTCCGATCCGCAC
TCGATGAAGGCGAGGCCAGCGGCGACTTTCAGGAGTTCGACGCCGACACCTTCCTCGCCTCGATGCGCCAGCCTGCCGGG
CAATAG

Structures

Toxin

• AlphaFold DB: B1Z8T2

Antitoxin

• AlphaFold DB: B1Z8T3