Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 369713..370356 Replicon chromosome
Accession NZ_CP089777
Organism Mycobacterium tuberculosis strain I0003270-1

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag LVJ72_RS01605 Protein ID WP_003401566.1
Coordinates 369931..370356 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag LVJ72_RS01600 Protein ID WP_003401563.1
Coordinates 369713..369934 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ72_RS01575 (LVJ72_01575) 364832..365635 - 804 WP_003401540.1 Stf0 family sulphotransferase -
LVJ72_RS01580 (LVJ72_01580) 365645..367042 - 1398 WP_003401544.1 sulfatase -
LVJ72_RS01585 (LVJ72_01585) 367221..368996 + 1776 WP_010886074.1 PE family protein -
LVJ72_RS01590 (LVJ72_01590) 369139..369366 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
LVJ72_RS01595 (LVJ72_01595) 369363..369665 + 303 WP_003401560.1 toxin-antitoxin system toxin -
LVJ72_RS01600 (LVJ72_01600) 369713..369934 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
LVJ72_RS01605 (LVJ72_01605) 369931..370356 + 426 WP_003401566.1 PIN domain nuclease Toxin
LVJ72_RS01610 (LVJ72_01610) 370492..371124 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
LVJ72_RS01615 (LVJ72_01615) 371121..372029 + 909 WP_003900117.1 protochlorophyllide reductase -
LVJ72_RS01620 (LVJ72_01620) 372037..372627 - 591 WP_229298012.1 hypothetical protein -
LVJ72_RS01625 (LVJ72_01625) 372620..372670 - 51 Protein_321 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T228966 WP_003401566.1 NZ_CP089777:369931-370356 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T228966 NZ_CP124359:2010884-2011138 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT228966 WP_003401563.1 NZ_CP089777:369713-369934 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT228966 NZ_CP124359:2010636-2010887 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References