Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 5287088..5287673 Replicon chromosome
Accession NC_010725
Organism Methylobacterium populi BJ001

Toxin (Protein)


Gene name PumA Uniprot ID B1ZLX5
Locus tag MPOP_RS24480 Protein ID WP_012456642.1
Coordinates 5287088..5287393 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1ZLX6
Locus tag MPOP_RS24485 Protein ID WP_012456643.1
Coordinates 5287383..5287673 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPOP_RS24455 5282303..5283709 - 1407 WP_012456637.1 adenosylhomocysteinase -
MPOP_RS27265 5283908..5284288 - 381 WP_052300078.1 hypothetical protein -
MPOP_RS27990 5284293..5284559 - 267 WP_012456639.1 DUF433 domain-containing protein -
MPOP_RS24470 5284620..5286245 - 1626 WP_081435434.1 AMP-binding protein -
MPOP_RS24475 5286350..5286961 - 612 WP_012456641.1 nitroreductase family protein -
MPOP_RS24480 5287088..5287393 + 306 WP_012456642.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MPOP_RS24485 5287383..5287673 + 291 WP_012456643.1 putative addiction module antidote protein Antitoxin
MPOP_RS24490 5287729..5288526 + 798 WP_012456644.1 enoyl-CoA hydratase -
MPOP_RS24495 5288606..5289385 + 780 WP_012456645.1 endonuclease/exonuclease/phosphatase family protein -
MPOP_RS24500 5289276..5290712 - 1437 WP_012456646.1 cardiolipin synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11440.97 Da        Isoelectric Point: 9.7223

>T22896 WP_012456642.1 NC_010725:5287088-5287393 [Methylorubrum populi BJ001]
MPTIRQTRTYSDWFDGLMDRQAQARIDVRVRRLSLGNPGDVRHLTGGVSELRIDHGPGYRVSYTQRGQEIVILLCGGDKR
RQARDIALALEMAKEVWSDGS

Download         Length: 306 bp

>T22896 NC_010725:5287088-5287393 [Methylorubrum populi BJ001]
ATGCCGACGATCCGCCAGACCCGAACCTACAGCGACTGGTTCGATGGCTTGATGGATCGGCAGGCCCAAGCCCGGATCGA
TGTGCGTGTGCGCCGTCTTTCGCTCGGTAATCCGGGTGATGTGCGGCACCTGACCGGGGGCGTGTCCGAACTTCGGATCG
ATCACGGACCTGGATATCGGGTTTCCTATACGCAGCGGGGCCAGGAGATCGTCATTCTGCTGTGCGGCGGGGACAAGCGC
CGGCAGGCACGCGATATCGCGCTGGCTCTGGAGATGGCGAAGGAGGTTTGGTCTGATGGCTCTTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10349.82 Da        Isoelectric Point: 4.6412

>AT22896 WP_012456643.1 NC_010725:5287383-5287673 [Methylorubrum populi BJ001]
MALETKPWDVAEHLQDEEAMAAYIEAVLEDGDPALVAAAIGDIARARGMAQIARETGRSRESLYRALSDRGNPELATLMG
VLKAMGLQLSVRPRTA

Download         Length: 291 bp

>AT22896 NC_010725:5287383-5287673 [Methylorubrum populi BJ001]
ATGGCTCTTGAGACGAAGCCCTGGGACGTCGCCGAACATCTCCAGGACGAGGAGGCGATGGCTGCCTATATCGAGGCTGT
GCTGGAAGATGGCGACCCGGCTCTTGTCGCTGCCGCAATCGGGGACATCGCCCGTGCCCGGGGCATGGCGCAGATCGCCC
GCGAGACGGGGCGCTCACGCGAGAGTCTGTACCGGGCCCTCTCTGATAGGGGCAATCCGGAACTCGCGACCCTCATGGGT
GTGCTCAAGGCCATGGGGCTGCAACTGAGCGTGCGCCCGCGAACCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1ZLX5

Antitoxin

Source ID Structure
AlphaFold DB A0A177IRN2

References