Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3697041..3697715 Replicon chromosome
Accession NZ_CP089776
Organism Mycobacterium tuberculosis strain 02-R1896

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag LVJ71_RS17520 Protein ID WP_003417282.1
Coordinates 3697041..3697469 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag LVJ71_RS17525 Protein ID WP_003417286.1
Coordinates 3697473..3697715 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ71_RS17495 (LVJ71_17495) 3692863..3693264 - 402 WP_003417264.1 cytidine deaminase -
LVJ71_RS17500 (LVJ71_17500) 3693501..3693839 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
LVJ71_RS17505 (LVJ71_17505) 3693836..3694270 + 435 WP_003913036.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
LVJ71_RS17510 (LVJ71_17510) 3694399..3696171 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
LVJ71_RS17515 (LVJ71_17515) 3696171..3696962 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
LVJ71_RS17520 (LVJ71_17520) 3697041..3697469 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ71_RS17525 (LVJ71_17525) 3697473..3697715 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
LVJ71_RS17530 (LVJ71_17530) 3697837..3698451 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
LVJ71_RS17535 (LVJ71_17535) 3698448..3699113 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
LVJ71_RS17540 (LVJ71_17540) 3699114..3699647 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
LVJ71_RS17545 (LVJ71_17545) 3699644..3700018 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
LVJ71_RS17550 (LVJ71_17550) 3700115..3701251 - 1137 WP_003417297.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T228959 WP_003417282.1 NZ_CP089776:c3697469-3697041 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T228959 NZ_CP124359:188541-188648 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT228959 WP_003417286.1 NZ_CP089776:c3697715-3697473 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT228959 NZ_CP124359:c188484-188427 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References