Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3169398..3169946 Replicon chromosome
Accession NZ_CP089776
Organism Mycobacterium tuberculosis strain 02-R1896

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag LVJ71_RS15135 Protein ID WP_003414602.1
Coordinates 3169683..3169946 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag LVJ71_RS15130 Protein ID WP_003414599.1
Coordinates 3169398..3169679 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ71_RS15105 (LVJ71_15105) 3165021..3165878 - 858 WP_003899513.1 type I methionyl aminopeptidase -
LVJ71_RS15110 (LVJ71_15110) 3165920..3166504 - 585 WP_003899514.1 DUF1707 domain-containing protein -
LVJ71_RS15115 (LVJ71_15115) 3166608..3166856 + 249 WP_003913411.1 antitoxin VapB23 -
LVJ71_RS15120 (LVJ71_15120) 3166853..3167233 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
LVJ71_RS15125 (LVJ71_15125) 3167315..3169126 - 1812 WP_003414596.1 penicillin-binding protein -
LVJ71_RS15130 (LVJ71_15130) 3169398..3169679 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
LVJ71_RS15135 (LVJ71_15135) 3169683..3169946 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ71_RS15140 (LVJ71_15140) 3170319..3171173 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
LVJ71_RS15145 (LVJ71_15145) 3171229..3172392 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
LVJ71_RS15150 (LVJ71_15150) 3172409..3173623 - 1215 WP_003899518.1 zinc metalloprotease Rip -
LVJ71_RS15155 (LVJ71_15155) 3173631..3174872 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T228956 WP_003414602.1 NZ_CP089776:3169683-3169946 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T228956 NZ_CP124357:c4544185-4544012 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT228956 WP_003414599.1 NZ_CP089776:3169398-3169679 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT228956 NZ_CP124357:c4544509-4544213 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCCGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References