Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2922104..2922818 Replicon chromosome
Accession NZ_CP089776
Organism Mycobacterium tuberculosis strain 02-R1896

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag LVJ71_RS13730 Protein ID WP_003413460.1
Coordinates 2922378..2922818 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag LVJ71_RS13725 Protein ID WP_003413456.1
Coordinates 2922104..2922391 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ71_RS13690 (LVJ71_13690) 2917526..2917771 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LVJ71_RS13695 (LVJ71_13695) 2917768..2918172 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
LVJ71_RS13700 (LVJ71_13700) 2918389..2919009 + 621 WP_003912795.1 DUF4178 domain-containing protein -
LVJ71_RS13705 (LVJ71_13705) 2919020..2919514 + 495 WP_003413444.1 DUF2617 family protein -
LVJ71_RS13710 (LVJ71_13710) 2919511..2919942 + 432 WP_003899390.1 DUF4247 domain-containing protein -
LVJ71_RS13715 (LVJ71_13715) 2919967..2920425 + 459 WP_003413451.1 DUF350 domain-containing protein -
LVJ71_RS13720 (LVJ71_13720) 2920422..2921993 + 1572 WP_070897530.1 polyamine aminopropyltransferase -
LVJ71_RS13725 (LVJ71_13725) 2922104..2922391 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
LVJ71_RS13730 (LVJ71_13730) 2922378..2922818 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ71_RS13735 (LVJ71_13735) 2922839..2923594 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
LVJ71_RS13740 (LVJ71_13740) 2923727..2924323 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
LVJ71_RS13745 (LVJ71_13745) 2924331..2925176 - 846 WP_003413466.1 acyl-CoA thioesterase II -
LVJ71_RS13750 (LVJ71_13750) 2925205..2926104 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
LVJ71_RS13755 (LVJ71_13755) 2926232..2926906 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T228949 WP_003413460.1 NZ_CP089776:2922378-2922818 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T228949 NZ_CP124357:c3598220-3597918 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT228949 WP_003413456.1 NZ_CP089776:2922104-2922391 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT228949 NZ_CP124357:c3597882-3597541 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References