Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2360184..2360879 Replicon chromosome
Accession NZ_CP089776
Organism Mycobacterium tuberculosis strain 02-R1896

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag LVJ71_RS11045 Protein ID WP_003410811.1
Coordinates 2360184..2360618 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag LVJ71_RS11050 Protein ID WP_003410814.1
Coordinates 2360625..2360879 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ71_RS11035 (LVJ71_11045) 2356338..2359379 + 3042 WP_070897520.1 DEAD/DEAH box helicase -
LVJ71_RS11040 (LVJ71_11050) 2359372..2360205 + 834 WP_003899172.1 SWIM zinc finger family protein -
LVJ71_RS11045 (LVJ71_11055) 2360184..2360618 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ71_RS11050 (LVJ71_11060) 2360625..2360879 - 255 WP_003410814.1 antitoxin Antitoxin
LVJ71_RS11055 (LVJ71_11065) 2360895..2361152 - 258 WP_003410816.1 hypothetical protein -
LVJ71_RS11060 (LVJ71_11070) 2362099..2362395 + 297 WP_003410820.1 PE family protein -
LVJ71_RS11065 (LVJ71_11075) 2362451..2363182 + 732 WP_003900467.1 PPE family protein -
LVJ71_RS11070 (LVJ71_11080) 2363722..2364468 - 747 WP_003906749.1 proteasome subunit alpha -
LVJ71_RS11075 (LVJ71_11085) 2364465..2365340 - 876 WP_003411023.1 proteasome subunit beta -
LVJ71_RS11080 (LVJ71_11090) 2365337..2365531 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T228942 WP_003410811.1 NZ_CP089776:c2360618-2360184 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T228942 NZ_CP124357:2000701-2000952 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT228942 WP_003410814.1 NZ_CP089776:c2360879-2360625 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT228942 NZ_CP124357:2000949-2001203 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References