Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2223988..2224886 Replicon chromosome
Accession NZ_CP089776
Organism Mycobacterium tuberculosis strain 02-R1896

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag LVJ71_RS10440 Protein ID WP_003410001.1
Coordinates 2223988..2224548 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag LVJ71_RS10445 Protein ID WP_003410003.1
Coordinates 2224545..2224886 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ71_RS10410 (LVJ71_10420) 2219157..2219810 - 654 WP_003409976.1 cutinase Cfp21 -
LVJ71_RS10415 (LVJ71_10425) 2219925..2220155 + 231 WP_003409980.1 DUF167 domain-containing protein -
LVJ71_RS10420 (LVJ71_10430) 2220240..2221151 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
LVJ71_RS10425 (LVJ71_10435) 2221260..2221859 + 600 WP_003409989.1 L-lysine exporter -
LVJ71_RS10430 (LVJ71_10440) 2222275..2222703 + 429 WP_003409992.1 cellulose-binding protein -
LVJ71_RS10435 (LVJ71_10445) 2222929..2223468 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
LVJ71_RS10440 (LVJ71_10450) 2223988..2224548 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
LVJ71_RS10445 (LVJ71_10455) 2224545..2224886 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
LVJ71_RS10450 (LVJ71_10460) 2224972..2225229 + 258 WP_003410006.1 hypothetical protein -
LVJ71_RS10455 (LVJ71_10465) 2225130..2225465 - 336 WP_003410009.1 dehydrogenase -
LVJ71_RS10460 (LVJ71_10470) 2225554..2225898 - 345 WP_003912702.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
LVJ71_RS10465 (LVJ71_10475) 2225892..2226140 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
LVJ71_RS10470 (LVJ71_10480) 2226240..2228555 - 2316 WP_003899120.1 cation transporter ATPase CptG -
LVJ71_RS10475 (LVJ71_10485) 2228552..2228824 - 273 WP_003410017.1 DUF1490 family protein -
LVJ71_RS10480 (LVJ71_10490) 2228877..2229233 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T228937 WP_003410001.1 NZ_CP089776:c2224548-2223988 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T228937 NZ_CP124357:291052-291579 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT228937 WP_003410003.1 NZ_CP089776:c2224886-2224545 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT228937 NZ_CP124357:290779-291045 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References