Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2216662..2217350 Replicon chromosome
Accession NZ_CP089776
Organism Mycobacterium tuberculosis strain 02-R1896

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag LVJ71_RS10395 Protein ID WP_003409958.1
Coordinates 2216662..2217081 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag LVJ71_RS10400 Protein ID WP_003409968.1
Coordinates 2217090..2217350 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ71_RS10375 (LVJ71_10385) 2212157..2213005 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
LVJ71_RS10380 (LVJ71_10390) 2212968..2214413 - 1446 WP_003899115.1 APC family permease -
LVJ71_RS10385 (LVJ71_10395) 2214592..2215278 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
LVJ71_RS10390 (LVJ71_10400) 2215469..2216437 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
LVJ71_RS10395 (LVJ71_10405) 2216662..2217081 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ71_RS10400 (LVJ71_10410) 2217090..2217350 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ71_RS10405 (LVJ71_10415) 2217493..2219169 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
LVJ71_RS10410 (LVJ71_10420) 2219157..2219810 - 654 WP_003409976.1 cutinase Cfp21 -
LVJ71_RS10415 (LVJ71_10425) 2219925..2220155 + 231 WP_003409980.1 DUF167 domain-containing protein -
LVJ71_RS10420 (LVJ71_10430) 2220240..2221151 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
LVJ71_RS10425 (LVJ71_10435) 2221260..2221859 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T228936 WP_003409958.1 NZ_CP089776:c2217081-2216662 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T228936 NZ_CP124357:188541-188648 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT228936 WP_003409968.1 NZ_CP089776:c2217350-2217090 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT228936 NZ_CP124357:c188484-188427 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References