Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1950143..1950756 Replicon chromosome
Accession NZ_CP089776
Organism Mycobacterium tuberculosis strain 02-R1896

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag LVJ71_RS09105 Protein ID WP_003408465.1
Coordinates 1950143..1950532 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag LVJ71_RS09110 Protein ID WP_003408469.1
Coordinates 1950529..1950756 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ71_RS09070 (LVJ71_09075) 1945772..1946686 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
LVJ71_RS09075 (LVJ71_09080) 1946689..1947519 + 831 WP_003408448.1 cyclase family protein -
LVJ71_RS09080 (LVJ71_09085) 1947519..1947869 + 351 WP_003898986.1 cupin domain-containing protein -
LVJ71_RS09085 (LVJ71_09090) 1947922..1948740 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
LVJ71_RS09090 (LVJ71_09095) 1948754..1949533 + 780 WP_003408460.1 IclR family transcriptional regulator -
LVJ71_RS09100 (LVJ71_09105) 1949964..1950095 + 132 Protein_1795 IS3 family transposase -
LVJ71_RS09105 (LVJ71_09110) 1950143..1950532 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ71_RS09110 (LVJ71_09115) 1950529..1950756 - 228 WP_003408469.1 antitoxin Antitoxin
LVJ71_RS09115 (LVJ71_09120) 1950974..1952458 + 1485 WP_003408473.1 biotin carboxylase -
LVJ71_RS09120 (LVJ71_09125) 1952455..1953702 + 1248 WP_003408476.1 serine hydrolase -
LVJ71_RS09125 (LVJ71_09130) 1953745..1954164 - 420 WP_003408483.1 hypothetical protein -
LVJ71_RS09130 (LVJ71_09135) 1954154..1954864 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T228931 WP_003408465.1 NZ_CP089776:c1950532-1950143 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T228931 NZ_CP124355:c5212505-5212398 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT228931 WP_003408469.1 NZ_CP089776:c1950756-1950529 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT228931 NZ_CP124355:5212553-5212619 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References