22893

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 3360334..3360734 Replicon chromosome
Accession NC_010725
Organism Methylobacterium populi BJ001

Toxin (Protein)


Gene name hicA Uniprot ID B1ZGP7
Locus tag MPOP_RS15555 Protein ID WP_012454998.1
Coordinates 3360334..3360528 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B1ZGP8
Locus tag MPOP_RS15560 Protein ID WP_012454999.1
Coordinates 3360528..3360734 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPOP_RS15535 3356223..3357335 + 1113 WP_012454995.1 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase -
MPOP_RS15540 3357453..3358859 + 1407 WP_012454996.1 UDP-N-acetylmuramate--L-alanine ligase -
MPOP_RS15545 3358863..3359401 + 539 Protein_3115 endonuclease domain-containing protein -
MPOP_RS15550 3359398..3360327 + 930 WP_012454997.1 UDP-N-acetylmuramate dehydrogenase -
MPOP_RS15555 3360334..3360528 + 195 WP_012454998.1 type II toxin-antitoxin system HicA family toxin Toxin
MPOP_RS15560 3360528..3360734 + 207 WP_012454999.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MPOP_RS15565 3360798..3361721 + 924 WP_012455000.1 D-alanine--D-alanine ligase -
MPOP_RS15570 3361688..3362626 + 939 WP_012455001.1 cell division protein FtsQ/DivIB -
MPOP_RS15575 3362689..3364011 + 1323 WP_012455002.1 cell division protein FtsA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3300557..3370053 69496


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7019.12 Da        Isoelectric Point: 10.9929

>T22893 WP_012454998.1 NC_010725:3360334-3360528 [Methylorubrum populi BJ001]
MKVREIIRLIETDGWTLVATRGSHRQYKHPTKPGRVTVAGAMSDEVAPGTRGSILKQAGLKGQY

Download         Length: 195 bp

>T22893 NC_010725:3360334-3360528 [Methylorubrum populi BJ001]
ATGAAGGTCCGCGAGATCATCCGCCTCATCGAGACCGATGGATGGACTCTCGTCGCGACACGGGGCTCGCACCGGCAGTA
CAAGCATCCGACGAAGCCCGGCCGCGTTACGGTGGCCGGGGCGATGTCGGACGAGGTCGCGCCCGGAACGCGGGGGAGCA
TCCTCAAGCAGGCGGGTCTGAAAGGACAGTACTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7351.16 Da        Isoelectric Point: 4.1947

>AT22893 WP_012454999.1 NC_010725:3360528-3360734 [Methylorubrum populi BJ001]
MRYAVVIERAGSNYSAYVPDLPGCIATAPTAEAVESEIRDAIRFHIEGLRADGDPVPEPTSRAEYVDA

Download         Length: 207 bp

>AT22893 NC_010725:3360528-3360734 [Methylorubrum populi BJ001]
ATGCGCTACGCCGTCGTCATCGAACGAGCCGGAAGCAACTACTCGGCCTACGTCCCCGATTTGCCGGGCTGCATCGCCAC
CGCCCCGACGGCTGAAGCCGTCGAAAGCGAGATCCGCGATGCCATCCGCTTCCACATCGAAGGCCTTCGTGCCGACGGCG
ATCCTGTGCCCGAGCCGACGAGCCGGGCCGAATACGTTGATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A177JAT4

Antitoxin

Source ID Structure
AlphaFold DB B1ZGP8

References