Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1021271..1021890 Replicon chromosome
Accession NZ_CP089776
Organism Mycobacterium tuberculosis strain 02-R1896

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag LVJ71_RS04845 Protein ID WP_003404726.1
Coordinates 1021456..1021890 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag LVJ71_RS04840 Protein ID WP_003898641.1
Coordinates 1021271..1021450 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ71_RS04825 (LVJ71_04820) 1016744..1018324 + 1581 WP_003909313.1 serine hydrolase -
LVJ71_RS04830 (LVJ71_04825) 1018321..1020714 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
LVJ71_RS04835 (LVJ71_04830) 1020987..1021145 + 159 WP_003404720.1 hypothetical protein -
LVJ71_RS04840 (LVJ71_04835) 1021271..1021450 + 180 WP_003898641.1 antitoxin Antitoxin
LVJ71_RS04845 (LVJ71_04840) 1021456..1021890 + 435 WP_003404726.1 SRPBCC family protein Toxin
LVJ71_RS04850 (LVJ71_04845) 1021988..1022761 + 774 WP_003404735.1 VOC family protein -
LVJ71_RS04855 (LVJ71_04850) 1022826..1023275 + 450 WP_003404738.1 hypothetical protein -
LVJ71_RS04860 (LVJ71_04855) 1023410..1023640 - 231 WP_003898642.1 hypothetical protein -
LVJ71_RS04865 (LVJ71_04860) 1023807..1025315 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
LVJ71_RS04870 (LVJ71_04865) 1025317..1026555 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T228920 WP_003404726.1 NZ_CP089776:1021456-1021890 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T228920 NZ_CP124355:c2656918-2656811 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT228920 WP_003898641.1 NZ_CP089776:1021271-1021450 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT228920 NZ_CP124355:2656967-2657032 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References