Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 448667..449678 Replicon chromosome
Accession NZ_CP089776
Organism Mycobacterium tuberculosis strain 02-R1896

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag LVJ71_RS01950 Protein ID WP_003401859.1
Coordinates 448667..449260 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag LVJ71_RS01955 Protein ID WP_003401860.1
Coordinates 449289..449678 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ71_RS01930 (LVJ71_01930) 444316..445698 + 1383 WP_003898415.1 magnesium transporter -
LVJ71_RS01935 (LVJ71_01935) 445710..446744 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
LVJ71_RS01940 (LVJ71_01940) 446840..447523 + 684 WP_003401857.1 VTT domain-containing protein -
LVJ71_RS01945 (LVJ71_01945) 447512..448642 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
LVJ71_RS01950 (LVJ71_01950) 448667..449260 - 594 WP_003401859.1 zeta toxin family protein Toxin
LVJ71_RS01955 (LVJ71_01955) 449289..449678 - 390 WP_003401860.1 hypothetical protein Antitoxin
LVJ71_RS01960 (LVJ71_01960) 449759..450970 - 1212 WP_003906353.1 VWA domain-containing protein -
LVJ71_RS01965 (LVJ71_01965) 450976..451578 - 603 WP_003898417.1 SRPBCC family protein -
LVJ71_RS01970 (LVJ71_01970) 451592..452488 - 897 WP_003898418.1 MoxR family ATPase -
LVJ71_RS01975 (LVJ71_01975) 452485..453078 - 594 WP_003401864.1 NTP transferase domain-containing protein -
LVJ71_RS01980 (LVJ71_01980) 453075..453830 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T228906 WP_003401859.1 NZ_CP089776:c449260-448667 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T228906 NZ_CP124354:c35883-35734 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT228906 WP_003401860.1 NZ_CP089776:c449678-449289 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT228906 NZ_CP124354:35927-35988 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References