Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 368370..369013 Replicon chromosome
Accession NZ_CP089776
Organism Mycobacterium tuberculosis strain 02-R1896

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag LVJ71_RS01610 Protein ID WP_003401566.1
Coordinates 368588..369013 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag LVJ71_RS01605 Protein ID WP_003401563.1
Coordinates 368370..368591 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ71_RS01580 (LVJ71_01580) 363489..364292 - 804 WP_003401540.1 Stf0 family sulphotransferase -
LVJ71_RS01585 (LVJ71_01585) 364302..365699 - 1398 WP_003914582.1 sulfatase -
LVJ71_RS01590 (LVJ71_01590) 365878..367653 + 1776 WP_010886074.1 PE family protein -
LVJ71_RS01595 (LVJ71_01595) 367796..368023 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
LVJ71_RS01600 (LVJ71_01600) 368020..368322 + 303 WP_003401560.1 toxin-antitoxin system toxin -
LVJ71_RS01605 (LVJ71_01605) 368370..368591 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
LVJ71_RS01610 (LVJ71_01610) 368588..369013 + 426 WP_003401566.1 PIN domain nuclease Toxin
LVJ71_RS01615 (LVJ71_01615) 369149..369781 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
LVJ71_RS01620 (LVJ71_01620) 369778..370686 + 909 WP_003900117.1 protochlorophyllide reductase -
LVJ71_RS01625 (LVJ71_01625) 370694..371284 - 591 WP_229298012.1 hypothetical protein -
LVJ71_RS01630 (LVJ71_01630) 371277..371327 - 51 Protein_322 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T228905 WP_003401566.1 NZ_CP089776:368588-369013 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T228905 NZ_CP124353:c5210962-5210855 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT228905 WP_003401563.1 NZ_CP089776:368370-368591 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT228905 NZ_CP124353:5211010-5211076 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References