Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09812-MazE
Location 844617..845266 Replicon chromosome
Accession NC_010725
Organism Methylobacterium populi BJ001

Toxin (Protein)


Gene name mazF Uniprot ID B1Z7Z2
Locus tag MPOP_RS03950 Protein ID WP_012452719.1
Coordinates 844617..844988 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID B1Z7Z3
Locus tag MPOP_RS03955 Protein ID WP_012452720.1
Coordinates 844988..845266 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPOP_RS03925 840687..840917 - 231 WP_012452714.1 hypothetical protein -
MPOP_RS03930 841028..842191 + 1164 WP_012452715.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
MPOP_RS03935 842197..843057 - 861 WP_012452716.1 C40 family peptidase -
MPOP_RS03940 843367..843738 + 372 WP_012452717.1 hypothetical protein -
MPOP_RS03945 843854..844540 - 687 WP_012452718.1 SDR family NAD(P)-dependent oxidoreductase -
MPOP_RS03950 844617..844988 - 372 WP_012452719.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MPOP_RS03955 844988..845266 - 279 WP_012452720.1 MazF family transcriptional regulator Antitoxin
MPOP_RS03960 845323..846039 - 717 WP_041371865.1 MgtC/SapB family protein -
MPOP_RS03965 846363..847358 + 996 WP_012452722.1 AAA family ATPase -
MPOP_RS03970 847364..848296 + 933 WP_012452723.1 DUF58 domain-containing protein -
MPOP_RS03975 848432..848887 + 456 WP_041371046.1 DUF4381 family protein -
MPOP_RS03980 848893..849912 + 1020 WP_012452725.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 12878.82 Da        Isoelectric Point: 8.0423

>T22890 WP_012452719.1 NC_010725:c844988-844617 [Methylorubrum populi BJ001]
MGPRPRIPKRGDIYSINPNPVAGREMRDRHYWLVLSPEAVNVHGVAITVVIATVAVGARAAGLAVPISAEGVTGVAVCTQ
LRSFDLRARIANGSASFAGTADIKTVEDVAARVADLLDPPPEV

Download         Length: 372 bp

>T22890 NC_010725:c844988-844617 [Methylorubrum populi BJ001]
ATGGGACCGCGGCCCCGTATTCCGAAGCGAGGGGACATCTATTCGATCAACCCGAACCCCGTCGCCGGCAGGGAAATGCG
CGATCGGCATTACTGGCTCGTCCTGAGCCCGGAGGCCGTCAACGTGCATGGCGTTGCAATCACCGTGGTGATCGCGACAG
TCGCGGTGGGAGCCCGCGCGGCGGGGCTTGCGGTTCCGATCTCCGCAGAGGGTGTGACGGGGGTGGCGGTCTGCACGCAA
TTGCGCAGCTTCGATCTGCGTGCCCGTATCGCCAACGGTAGCGCATCGTTTGCGGGGACGGCCGACATCAAAACGGTCGA
AGATGTCGCCGCGCGCGTCGCCGATCTGTTGGATCCTCCGCCCGAGGTTTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9583.13 Da        Isoelectric Point: 9.8281

>AT22890 WP_012452720.1 NC_010725:c845266-844988 [Methylorubrum populi BJ001]
MATIVKVRRQGGARIVTLPPALLARIGADAGTFLALDVKGGAIVAKPVADAPAPRRRRYTLSELLVGAEHLPDLYRSVEG
ALDGDPVGNEIG

Download         Length: 279 bp

>AT22890 NC_010725:c845266-844988 [Methylorubrum populi BJ001]
ATGGCCACCATCGTAAAAGTGCGACGCCAGGGCGGCGCGCGCATCGTCACTCTGCCTCCCGCGCTGTTGGCGCGGATCGG
GGCGGATGCCGGCACGTTTCTGGCTCTCGACGTCAAGGGCGGGGCGATCGTCGCCAAGCCGGTCGCTGACGCTCCGGCTC
CCCGTCGGCGGCGTTACACGCTGTCGGAGCTTCTCGTCGGAGCGGAGCACCTTCCGGATCTCTACCGTAGTGTCGAGGGC
GCTCTCGATGGTGATCCGGTCGGGAACGAGATCGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A177IU35

Antitoxin

Source ID Structure
AlphaFold DB B1Z7Z3

References