Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3773603..3774132 Replicon chromosome
Accession NZ_CP089775
Organism Mycobacterium tuberculosis strain 02-R1708

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag LVJ70_RS17745 Protein ID WP_003417760.1
Coordinates 3773875..3774132 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag LVJ70_RS17740 Protein ID WP_003417757.1
Coordinates 3773603..3773878 (+) Length 92 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ70_RS17705 (LVJ70_17705) 3770176..3770865 - 690 WP_003917774.1 BBE domain-containing protein -
LVJ70_RS17710 (LVJ70_17710) 3771052..3771423 - 372 WP_003417739.1 FAD-binding protein -
LVJ70_RS17715 (LVJ70_17715) 3771321..3771539 - 219 WP_157132559.1 hypothetical protein -
LVJ70_RS17720 (LVJ70_17720) 3771566..3771826 - 261 WP_003417741.1 hypothetical protein -
LVJ70_RS17725 (LVJ70_17725) 3771941..3772330 + 390 WP_003417745.1 DUF732 domain-containing protein -
LVJ70_RS17730 (LVJ70_17730) 3772344..3772637 - 294 WP_003417749.1 DUF3017 domain-containing protein -
LVJ70_RS17735 (LVJ70_17735) 3772634..3773479 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
LVJ70_RS17740 (LVJ70_17740) 3773603..3773878 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
LVJ70_RS17745 (LVJ70_17745) 3773875..3774132 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
LVJ70_RS17750 (LVJ70_17750) 3774174..3775364 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
LVJ70_RS17755 (LVJ70_17755) 3775481..3775849 + 369 WP_003417765.1 FHA domain-containing protein -
LVJ70_RS17760 (LVJ70_17760) 3775846..3776397 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
LVJ70_RS17765 (LVJ70_17765) 3776404..3776985 - 582 WP_003417769.1 ATP/GTP-binding protein -
LVJ70_RS17770 (LVJ70_17770) 3776966..3777334 - 369 WP_003417772.1 DUF742 domain-containing protein -
LVJ70_RS17775 (LVJ70_17775) 3777312..3777704 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-85)

Antitoxin

(2-72)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T228899 WP_003417760.1 NZ_CP089775:3773875-3774132 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T228899 NZ_CP124353:3686731-3687108 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT228899 WP_003417757.1 NZ_CP089775:3773603-3773878 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT228899 NZ_CP124353:3686273-3686641 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3OEI


Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References