Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/Txe-YefM |
Location | 3773603..3774132 | Replicon | chromosome |
Accession | NZ_CP089775 | ||
Organism | Mycobacterium tuberculosis strain 02-R1708 |
Toxin (Protein)
Gene name | relE | Uniprot ID | G0TI95 |
Locus tag | LVJ70_RS17745 | Protein ID | WP_003417760.1 |
Coordinates | 3773875..3774132 (+) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | G0TI94 |
Locus tag | LVJ70_RS17740 | Protein ID | WP_003417757.1 |
Coordinates | 3773603..3773878 (+) | Length | 92 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LVJ70_RS17705 (LVJ70_17705) | 3770176..3770865 | - | 690 | WP_003917774.1 | BBE domain-containing protein | - |
LVJ70_RS17710 (LVJ70_17710) | 3771052..3771423 | - | 372 | WP_003417739.1 | FAD-binding protein | - |
LVJ70_RS17715 (LVJ70_17715) | 3771321..3771539 | - | 219 | WP_157132559.1 | hypothetical protein | - |
LVJ70_RS17720 (LVJ70_17720) | 3771566..3771826 | - | 261 | WP_003417741.1 | hypothetical protein | - |
LVJ70_RS17725 (LVJ70_17725) | 3771941..3772330 | + | 390 | WP_003417745.1 | DUF732 domain-containing protein | - |
LVJ70_RS17730 (LVJ70_17730) | 3772344..3772637 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
LVJ70_RS17735 (LVJ70_17735) | 3772634..3773479 | - | 846 | WP_003417751.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
LVJ70_RS17740 (LVJ70_17740) | 3773603..3773878 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
LVJ70_RS17745 (LVJ70_17745) | 3773875..3774132 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
LVJ70_RS17750 (LVJ70_17750) | 3774174..3775364 | + | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
LVJ70_RS17755 (LVJ70_17755) | 3775481..3775849 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
LVJ70_RS17760 (LVJ70_17760) | 3775846..3776397 | - | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
LVJ70_RS17765 (LVJ70_17765) | 3776404..3776985 | - | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
LVJ70_RS17770 (LVJ70_17770) | 3776966..3777334 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
LVJ70_RS17775 (LVJ70_17775) | 3777312..3777704 | - | 393 | WP_003417776.1 | serine protease inhibitor | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T228899 WP_003417760.1 NZ_CP089775:3773875-3774132 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T228899 NZ_CP124353:3686731-3687108 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT228899 WP_003417757.1 NZ_CP089775:3773603-3773878 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT228899 NZ_CP124353:3686273-3686641 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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