Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3706904..3707578 Replicon chromosome
Accession NZ_CP089775
Organism Mycobacterium tuberculosis strain 02-R1708

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag LVJ70_RS17515 Protein ID WP_003417282.1
Coordinates 3706904..3707332 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag LVJ70_RS17520 Protein ID WP_003417286.1
Coordinates 3707336..3707578 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ70_RS17490 (LVJ70_17490) 3702726..3703127 - 402 WP_003417264.1 cytidine deaminase -
LVJ70_RS17495 (LVJ70_17495) 3703364..3703702 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
LVJ70_RS17500 (LVJ70_17500) 3703699..3704133 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
LVJ70_RS17505 (LVJ70_17505) 3704262..3706034 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
LVJ70_RS17510 (LVJ70_17510) 3706034..3706825 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
LVJ70_RS17515 (LVJ70_17515) 3706904..3707332 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ70_RS17520 (LVJ70_17520) 3707336..3707578 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
LVJ70_RS17525 (LVJ70_17525) 3707700..3708314 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
LVJ70_RS17530 (LVJ70_17530) 3708311..3708601 - 291 Protein_3462 molybdenum cofactor biosynthesis protein MoaE -
LVJ70_RS17540 (LVJ70_17540) 3709954..3710334 - 381 Protein_3464 molybdopterin converting factor subunit 1 -
LVJ70_RS17545 (LVJ70_17545) 3710335..3710868 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
LVJ70_RS17550 (LVJ70_17550) 3710865..3711239 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
LVJ70_RS17555 (LVJ70_17555) 3711336..3712472 - 1137 WP_003417297.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T228898 WP_003417282.1 NZ_CP089775:c3707332-3706904 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T228898 NZ_CP124353:3589705-3590055 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT228898 WP_003417286.1 NZ_CP089775:c3707578-3707336 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT228898 NZ_CP124353:3589460-3589711 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References