Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3069482..3070161 | Replicon | chromosome |
| Accession | NZ_CP089775 | ||
| Organism | Mycobacterium tuberculosis strain 02-R1708 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P9WF90 |
| Locus tag | LVJ70_RS14555 | Protein ID | WP_003414059.1 |
| Coordinates | 3069482..3069898 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | LVJ70_RS14560 | Protein ID | WP_003414061.1 |
| Coordinates | 3069895..3070161 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ70_RS14535 (LVJ70_14535) | 3065534..3066436 | - | 903 | WP_003900564.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| LVJ70_RS14540 (LVJ70_14540) | 3066505..3067257 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
| LVJ70_RS14545 (LVJ70_14550) | 3067501..3067776 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| LVJ70_RS14550 (LVJ70_14555) | 3067773..3069395 | - | 1623 | WP_003414057.1 | class I SAM-dependent DNA methyltransferase | - |
| LVJ70_RS14555 (LVJ70_14560) | 3069482..3069898 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | Toxin |
| LVJ70_RS14560 (LVJ70_14565) | 3069895..3070161 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LVJ70_RS14565 (LVJ70_14570) | 3070187..3070582 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ70_RS14570 (LVJ70_14575) | 3070579..3070848 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| LVJ70_RS14575 (LVJ70_14580) | 3070858..3071952 | - | 1095 | WP_003900565.1 | restriction endonuclease subunit S | - |
| LVJ70_RS14580 (LVJ70_14585) | 3071949..3072368 | - | 420 | WP_003414070.1 | winged helix-turn-helix domain-containing protein | - |
| LVJ70_RS14585 (LVJ70_14590) | 3072367..3072441 | + | 75 | Protein_2878 | hypothetical protein | - |
| LVJ70_RS14590 (LVJ70_14595) | 3072442..3072921 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| LVJ70_RS14595 (LVJ70_14600) | 3072992..3073792 | - | 801 | WP_003911953.1 | thymidylate synthase | - |
| LVJ70_RS14600 (LVJ70_14605) | 3073948..3074685 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15773.00 Da Isoelectric Point: 7.1294
>T228890 WP_003414059.1 NZ_CP089775:c3069898-3069482 [Mycobacterium tuberculosis]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
Download Length: 417 bp
>T228890 NZ_CP124353:c2201093-2200779 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT228890 WP_003414061.1 NZ_CP089775:c3070161-3069895 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT228890 NZ_CP124353:c2200782-2200366 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|