Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 825327..826071 Replicon chromosome
Accession NC_010725
Organism Methylobacterium populi BJ001

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag MPOP_RS03860 Protein ID WP_012452701.1
Coordinates 825667..826071 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag MPOP_RS03855 Protein ID WP_012452700.1
Coordinates 825327..825662 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPOP_RS03825 820653..822914 + 2262 WP_012452694.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
MPOP_RS03830 823063..823431 + 369 WP_012452695.1 fluoride efflux transporter CrcB -
MPOP_RS03835 823443..823880 + 438 WP_012452696.1 EamA family transporter -
MPOP_RS03840 823880..824542 + 663 WP_041371863.1 M15 family metallopeptidase -
MPOP_RS03845 824712..824999 + 288 WP_012452698.1 hypothetical protein -
MPOP_RS03850 824996..825322 + 327 WP_012452699.1 hypothetical protein -
MPOP_RS03855 825327..825662 - 336 WP_012452700.1 helix-turn-helix domain-containing protein Antitoxin
MPOP_RS03860 825667..826071 - 405 WP_012452701.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MPOP_RS03865 826164..826823 - 660 WP_012452702.1 MarR family winged helix-turn-helix transcriptional regulator -
MPOP_RS28195 826876..827034 + 159 WP_158022269.1 hypothetical protein -
MPOP_RS03870 827069..829267 + 2199 WP_012452703.1 glycosyltransferase -
MPOP_RS03875 829299..830066 + 768 WP_012452704.1 glucose-1-phosphate cytidylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(27-119)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-93)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15000.22 Da        Isoelectric Point: 8.5006

>T22889 WP_012452701.1 NC_010725:c826071-825667 [Methylorubrum populi BJ001]
MGICPYSAVSSAFLPLKECWFVGSSRKDLAAFPDEVRSAFGHALHEAQCGLEPYAAKALKGFGGRGVLEIIENHDGDTFR
AVYTVRFAEAIYVLHCFQKKSKRGIATPQHEIELIRTRLRDAEAMDRIRTKEGR

Download         Length: 405 bp

>T22889 NC_010725:c826071-825667 [Methylorubrum populi BJ001]
ATGGGTATATGCCCATATTCGGCTGTGTCGTCGGCATTCCTACCTTTGAAAGAATGTTGGTTCGTCGGGTCGAGCCGAAA
AGATCTGGCGGCATTTCCCGATGAGGTCAGAAGCGCGTTCGGTCACGCGCTTCACGAAGCTCAGTGCGGCCTGGAGCCGT
ATGCGGCCAAGGCTTTGAAGGGCTTCGGTGGTCGCGGCGTTCTCGAGATCATCGAGAATCACGATGGGGATACCTTTCGG
GCTGTTTATACGGTGCGCTTCGCCGAGGCGATCTACGTACTTCACTGCTTCCAGAAAAAGTCGAAGAGGGGCATCGCCAC
GCCGCAACACGAGATCGAGCTGATTCGAACTCGATTGCGCGATGCAGAAGCGATGGACCGGATCCGGACCAAGGAAGGAC
GTTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 11988.74 Da        Isoelectric Point: 8.7024

>AT22889 WP_012452700.1 NC_010725:c825662-825327 [Methylorubrum populi BJ001]
MKGTEDAYQSSGNIFADLELADAQELHLKSSLVIELRRQIEGRQLTQTAAAKILGMGQADLSKLLRGGLRGTSVERLMRM
LTAFDQDVEITVRPHSRAGGGGRITVTPVPA

Download         Length: 336 bp

>AT22889 NC_010725:c825662-825327 [Methylorubrum populi BJ001]
ATGAAGGGCACCGAAGACGCTTACCAGAGCAGCGGAAACATCTTCGCGGACTTGGAACTGGCGGACGCCCAGGAACTGCA
TCTCAAGTCCAGCCTCGTGATCGAGCTGCGGCGGCAGATCGAAGGCCGTCAGCTGACTCAGACCGCGGCGGCGAAGATCC
TCGGAATGGGGCAGGCCGACCTGTCGAAGCTGCTGCGCGGCGGCTTGCGTGGCACGTCCGTCGAGCGCCTGATGCGGATG
CTGACCGCTTTCGATCAGGATGTGGAGATCACGGTGCGCCCGCATTCCCGGGCGGGCGGGGGCGGACGCATCACAGTGAC
GCCCGTCCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References