Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2930582..2931296 Replicon chromosome
Accession NZ_CP089775
Organism Mycobacterium tuberculosis strain 02-R1708

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag LVJ70_RS13735 Protein ID WP_003413460.1
Coordinates 2930856..2931296 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag LVJ70_RS13730 Protein ID WP_003413456.1
Coordinates 2930582..2930869 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ70_RS13695 (LVJ70_13695) 2926004..2926249 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LVJ70_RS13700 (LVJ70_13700) 2926246..2926650 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
LVJ70_RS13705 (LVJ70_13705) 2926867..2927487 + 621 WP_003413441.1 DUF4178 domain-containing protein -
LVJ70_RS13710 (LVJ70_13710) 2927498..2927992 + 495 WP_003413444.1 DUF2617 family protein -
LVJ70_RS13715 (LVJ70_13715) 2927989..2928420 + 432 WP_003899390.1 DUF4247 domain-containing protein -
LVJ70_RS13720 (LVJ70_13720) 2928445..2928903 + 459 WP_003413451.1 DUF350 domain-containing protein -
LVJ70_RS13725 (LVJ70_13725) 2928900..2930471 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
LVJ70_RS13730 (LVJ70_13730) 2930582..2930869 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
LVJ70_RS13735 (LVJ70_13735) 2930856..2931296 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ70_RS13740 (LVJ70_13740) 2931317..2932072 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
LVJ70_RS13745 (LVJ70_13745) 2932205..2932801 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
LVJ70_RS13750 (LVJ70_13750) 2932809..2933654 - 846 WP_003413466.1 acyl-CoA thioesterase II -
LVJ70_RS13755 (LVJ70_13755) 2933683..2934582 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
LVJ70_RS13760 (LVJ70_13760) 2934710..2935384 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T228888 WP_003413460.1 NZ_CP089775:2930856-2931296 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T228888 NZ_CP124353:c1890526-1890119 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT228888 WP_003413456.1 NZ_CP089775:2930582-2930869 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT228888 NZ_CP124353:c1890773-1890507 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References