Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2407454..2407983 Replicon chromosome
Accession NZ_CP089775
Organism Mycobacterium tuberculosis strain 02-R1708

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag LVJ70_RS11275 Protein ID WP_003411124.1
Coordinates 2407454..2407771 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag LVJ70_RS11280 Protein ID WP_003411127.1
Coordinates 2407768..2407983 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ70_RS11245 (LVJ70_11255) 2402475..2403551 + 1077 WP_003411110.1 hypothetical protein -
LVJ70_RS11250 (LVJ70_11260) 2403548..2403829 + 282 WP_003411112.1 DUF5703 family protein -
LVJ70_RS11255 (LVJ70_11265) 2403865..2404938 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
LVJ70_RS11260 (LVJ70_11270) 2404943..2405473 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
LVJ70_RS11265 (LVJ70_11275) 2405521..2406867 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
LVJ70_RS11275 (LVJ70_11285) 2407454..2407771 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ70_RS11280 (LVJ70_11290) 2407768..2407983 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
LVJ70_RS11285 (LVJ70_11295) 2408238..2409296 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
LVJ70_RS11290 (LVJ70_11300) 2409426..2409782 - 357 WP_003411130.1 hypothetical protein -
LVJ70_RS11295 (LVJ70_11305) 2409877..2410659 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
LVJ70_RS11300 (LVJ70_11310) 2410927..2411217 - 291 WP_003900476.1 YggT family protein -
LVJ70_RS11305 (LVJ70_11315) 2411379..2412035 - 657 WP_015456354.1 cell division protein SepF -
LVJ70_RS11310 (LVJ70_11320) 2412101..2412877 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T228882 WP_003411124.1 NZ_CP089775:c2407771-2407454 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T228882 NZ_CP124352:95821-96237 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT228882 WP_003411127.1 NZ_CP089775:c2407983-2407768 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT228882 NZ_CP124352:95594-95824 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References