Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2370533..2371228 Replicon chromosome
Accession NZ_CP089775
Organism Mycobacterium tuberculosis strain 02-R1708

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag LVJ70_RS11065 Protein ID WP_003410811.1
Coordinates 2370533..2370967 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag LVJ70_RS11070 Protein ID WP_003410814.1
Coordinates 2370974..2371228 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ70_RS11050 (LVJ70_11060) 2366722..2368260 + 1539 WP_023637436.1 HNH endonuclease signature motif containing protein -
LVJ70_RS11055 (LVJ70_11065) 2368459..2370129 + 1671 Protein_2186 SNF2 helicase-associated domain-containing protein -
LVJ70_RS11060 (LVJ70_11070) 2370132..2370554 + 423 Protein_2187 SWIM zinc finger family protein -
LVJ70_RS11065 (LVJ70_11075) 2370533..2370967 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ70_RS11070 (LVJ70_11080) 2370974..2371228 - 255 WP_003410814.1 antitoxin Antitoxin
LVJ70_RS11075 (LVJ70_11085) 2371244..2371501 - 258 WP_003410816.1 hypothetical protein -
LVJ70_RS11080 (LVJ70_11090) 2372448..2372744 + 297 WP_003410820.1 PE family protein -
LVJ70_RS11085 (LVJ70_11095) 2372800..2373531 + 732 WP_003900467.1 PPE family protein -
LVJ70_RS11090 (LVJ70_11100) 2374071..2374817 - 747 WP_003899174.1 proteasome subunit alpha -
LVJ70_RS11095 (LVJ70_11105) 2374814..2375689 - 876 WP_003411023.1 proteasome subunit beta -
LVJ70_RS11100 (LVJ70_11110) 2375686..2375880 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T228881 WP_003410811.1 NZ_CP089775:c2370967-2370533 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T228881 NZ_CP124352:c94814-94509 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT228881 WP_003410814.1 NZ_CP089775:c2371228-2370974 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT228881 NZ_CP124352:c95034-94816 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References