Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 784215..784894 Replicon chromosome
Accession NC_010725
Organism Methylobacterium populi BJ001

Toxin (Protein)


Gene name vapC Uniprot ID B1Z723
Locus tag MPOP_RS03670 Protein ID WP_012452662.1
Coordinates 784469..784894 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B1Z722
Locus tag MPOP_RS03665 Protein ID WP_012452661.1
Coordinates 784215..784472 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPOP_RS03645 779895..781286 + 1392 WP_041371036.1 hypothetical protein -
MPOP_RS03650 781283..781828 + 546 WP_012452658.1 hypothetical protein -
MPOP_RS03655 781875..783044 + 1170 WP_012452659.1 hypothetical protein -
MPOP_RS03660 783126..784142 + 1017 WP_012452660.1 serine protease -
MPOP_RS03665 784215..784472 + 258 WP_012452661.1 Arc family DNA-binding protein Antitoxin
MPOP_RS03670 784469..784894 + 426 WP_012452662.1 type II toxin-antitoxin system VapC family toxin Toxin
MPOP_RS03675 785020..785868 + 849 WP_012452663.1 OmpA family protein -
MPOP_RS03680 785915..786886 + 972 WP_041371038.1 hypothetical protein -
MPOP_RS03685 786955..787968 + 1014 WP_012452665.1 hypothetical protein -
MPOP_RS03690 788222..788485 + 264 WP_012452666.1 hypothetical protein -
MPOP_RS03695 788548..789123 + 576 WP_012452667.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(9-47)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15113.43 Da        Isoelectric Point: 6.3452

>T22888 WP_012452662.1 NC_010725:784469-784894 [Methylorubrum populi BJ001]
MIVLDTNVISELWRVAPDARVVAWVDAQAIETLYLTAITVAELRFGTATMPPGRRRDIFRDRLENTVLPAFTGRVLPFDL
DASRLYADLMARARAAGRAIGMADGLIAAAAAVRGFSVATRDTGPFEAAGVGVVNPWQAGV

Download         Length: 426 bp

>T22888 NC_010725:784469-784894 [Methylorubrum populi BJ001]
ATGATCGTCCTCGACACGAACGTCATCTCGGAGCTGTGGCGGGTCGCCCCCGACGCGCGCGTTGTGGCCTGGGTCGATGC
GCAGGCGATCGAAACGCTTTACCTCACGGCGATCACCGTTGCGGAACTCCGCTTCGGCACGGCGACGATGCCGCCAGGCA
GGCGACGGGACATCTTTCGGGATCGGCTGGAGAACACGGTGCTGCCGGCCTTCACCGGCCGCGTGCTGCCCTTCGATCTC
GATGCCTCACGCCTCTACGCCGACCTCATGGCGCGGGCGCGCGCCGCGGGCAGGGCCATCGGCATGGCAGACGGCTTGAT
CGCGGCCGCCGCGGCCGTCCGGGGCTTTTCCGTGGCGACCCGTGACACCGGCCCGTTCGAGGCCGCCGGGGTCGGCGTCG
TCAATCCGTGGCAGGCCGGCGTCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9289.44 Da        Isoelectric Point: 6.4706

>AT22888 WP_012452661.1 NC_010725:784215-784472 [Methylorubrum populi BJ001]
VASITIRNVPEEVHRALRVRATQHGRSTEAEIRAILEQATKPAGRLQLGSLLASIAREAGGLTETEADAFDRLRDTSPAE
PLRFE

Download         Length: 258 bp

>AT22888 NC_010725:784215-784472 [Methylorubrum populi BJ001]
GTGGCGTCGATCACCATCCGCAACGTTCCCGAAGAGGTGCACCGTGCCCTGCGCGTCCGGGCGACGCAGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAACAGGCGACCAAGCCGGCGGGCCGATTGCAGCTCGGCTCCCTGCTCGCCT
CCATCGCCCGCGAGGCCGGCGGCCTGACCGAGACGGAAGCGGACGCCTTCGACCGGCTTCGCGACACGTCGCCCGCCGAA
CCGCTCCGATTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1Z723

Antitoxin

Source ID Structure
AlphaFold DB A0A177IUB0

References