Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 2236222..2236808 | Replicon | chromosome |
| Accession | NZ_CP089775 | ||
| Organism | Mycobacterium tuberculosis strain 02-R1708 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G0TLY3 |
| Locus tag | LVJ70_RS10470 | Protein ID | WP_003410010.1 |
| Coordinates | 2236222..2236566 (-) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | P0CL58 |
| Locus tag | LVJ70_RS10475 | Protein ID | WP_003410014.1 |
| Coordinates | 2236560..2236808 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ70_RS10435 (LVJ70_10445) | 2231928..2232527 | + | 600 | WP_003409989.1 | L-lysine exporter | - |
| LVJ70_RS10440 (LVJ70_10450) | 2232943..2233371 | + | 429 | WP_003409992.1 | cellulose-binding protein | - |
| LVJ70_RS10445 (LVJ70_10455) | 2233597..2234136 | + | 540 | WP_003900446.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) | - |
| LVJ70_RS10450 (LVJ70_10460) | 2234656..2235216 | - | 561 | WP_003410001.1 | RES family NAD+ phosphorylase | - |
| LVJ70_RS10455 (LVJ70_10465) | 2235213..2235554 | - | 342 | WP_003410003.1 | DUF2384 domain-containing protein | - |
| LVJ70_RS10460 (LVJ70_10470) | 2235640..2235897 | + | 258 | WP_003410006.1 | hypothetical protein | - |
| LVJ70_RS10465 (LVJ70_10475) | 2235798..2236133 | - | 336 | WP_003410009.1 | dehydrogenase | - |
| LVJ70_RS10470 (LVJ70_10480) | 2236222..2236566 | - | 345 | WP_003410010.1 | type II toxin-antitoxin system toxin endoribonuclease MazF6 | Toxin |
| LVJ70_RS10475 (LVJ70_10485) | 2236560..2236808 | - | 249 | WP_003410014.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
| LVJ70_RS10480 (LVJ70_10490) | 2236908..2239223 | - | 2316 | WP_003899120.1 | cation transporter ATPase CptG | - |
| LVJ70_RS10485 (LVJ70_10495) | 2239220..2239492 | - | 273 | WP_003410017.1 | DUF1490 family protein | - |
| LVJ70_RS10490 (LVJ70_10500) | 2239545..2239901 | - | 357 | WP_003410018.1 | Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR | - |
| LVJ70_RS10495 (LVJ70_10505) | 2240058..2240825 | + | 768 | WP_003900447.1 | hemerythrin domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 12230.12 Da Isoelectric Point: 9.8887
>T228877 WP_003410010.1 NZ_CP089775:c2236566-2236222 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
Download Length: 345 bp
>T228877 NZ_CP124351:c4331629-4331411 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9290.34 Da Isoelectric Point: 4.3757
>AT228877 WP_003410014.1 NZ_CP089775:c2236808-2236560 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW
Download Length: 249 bp
>AT228877 NZ_CP124351:c4332029-4331655 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|