Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2205597..2206141 | Replicon | chromosome |
| Accession | NZ_CP089775 | ||
| Organism | Mycobacterium tuberculosis strain 02-R1708 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | LVJ70_RS10285 | Protein ID | WP_003409896.1 |
| Coordinates | 2205597..2205893 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | LVJ70_RS10290 | Protein ID | WP_003409899.1 |
| Coordinates | 2205890..2206141 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ70_RS10230 (LVJ70_10240) | 2200630..2200980 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| LVJ70_RS10235 (LVJ70_10245) | 2200991..2201893 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| LVJ70_RS10240 (LVJ70_10250) | 2201914..2202105 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| LVJ70_RS10245 (LVJ70_10255) | 2202106..2202402 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| LVJ70_RS10250 (LVJ70_10260) | 2202642..2202857 | + | 216 | WP_003409878.1 | antitoxin | - |
| LVJ70_RS10255 (LVJ70_10265) | 2202854..2203165 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ70_RS10260 (LVJ70_10270) | 2203139..2203660 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| LVJ70_RS10265 (LVJ70_10275) | 2203635..2204012 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| LVJ70_RS10270 (LVJ70_10280) | 2204054..2204503 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| LVJ70_RS10275 (LVJ70_10285) | 2204500..2205045 | + | 546 | WP_003899098.1 | SecB-like chaperone | - |
| LVJ70_RS10280 (LVJ70_10290) | 2204934..2205548 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| LVJ70_RS10285 (LVJ70_10295) | 2205597..2205893 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LVJ70_RS10290 (LVJ70_10300) | 2205890..2206141 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| LVJ70_RS10295 (LVJ70_10305) | 2206128..2206622 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| LVJ70_RS10300 (LVJ70_10310) | 2206782..2207189 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ70_RS10305 (LVJ70_10315) | 2207193..2207465 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LVJ70_RS10310 (LVJ70_10320) | 2207498..2208718 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| LVJ70_RS10315 (LVJ70_10325) | 2209617..2210414 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T228874 WP_003409896.1 NZ_CP089775:c2205893-2205597 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T228874 NZ_CP124351:3770027-3770314 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT228874 WP_003409899.1 NZ_CP089775:c2206141-2205890 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT228874 NZ_CP124351:3770301-3770603 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |