Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1578199..1578854 Replicon chromosome
Accession NZ_CP089775
Organism Mycobacterium tuberculosis strain 02-R1708

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag LVJ70_RS07480 Protein ID WP_003898861.1
Coordinates 1578199..1578600 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag LVJ70_RS07485 Protein ID WP_003407272.1
Coordinates 1578597..1578854 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ70_RS07465 (LVJ70_07465) 1573672..1575057 - 1386 WP_003407260.1 cytochrome P450 -
LVJ70_RS07470 (LVJ70_07470) 1575135..1576169 + 1035 WP_003407264.1 AraC family transcriptional regulator -
LVJ70_RS07475 (LVJ70_07475) 1576215..1577944 - 1730 Protein_1472 PE family protein -
LVJ70_RS07480 (LVJ70_07480) 1578199..1578600 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ70_RS07485 (LVJ70_07485) 1578597..1578854 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
LVJ70_RS07490 (LVJ70_07490) 1578937..1579896 - 960 WP_003407276.1 alpha/beta hydrolase -
LVJ70_RS07495 (LVJ70_07495) 1579921..1580883 - 963 WP_003407279.1 alpha/beta hydrolase -
LVJ70_RS07500 (LVJ70_07500) 1580882..1581619 + 738 WP_031647000.1 lysoplasmalogenase -
LVJ70_RS07505 (LVJ70_07505) 1581700..1583667 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T228867 WP_003898861.1 NZ_CP089775:c1578600-1578199 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T228867 NZ_CP124351:c2656348-2656241 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT228867 WP_003407272.1 NZ_CP089775:c1578854-1578597 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT228867 NZ_CP124351:2656405-2656462 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References