Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 758446..759079 Replicon chromosome
Accession NZ_CP089775
Organism Mycobacterium tuberculosis strain 02-R1708

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag LVJ70_RS03500 Protein ID WP_003403365.1
Coordinates 758446..758829 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag LVJ70_RS03505 Protein ID WP_003403368.1
Coordinates 758924..759079 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ70_RS03475 (LVJ70_03470) 753738..754274 + 537 WP_003403341.1 50S ribosomal protein L10 -
LVJ70_RS03480 (LVJ70_03475) 754311..754703 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
LVJ70_RS03485 (LVJ70_03480) 754696..755391 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
LVJ70_RS03490 (LVJ70_03485) 755462..756967 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
LVJ70_RS03495 (LVJ70_03490) 757048..758058 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
LVJ70_RS03500 (LVJ70_03495) 758446..758829 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
LVJ70_RS03505 (LVJ70_03500) 758924..759079 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ70_RS03510 (LVJ70_03505) 759155..759871 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
LVJ70_RS03515 (LVJ70_03510) 760147..760455 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
LVJ70_RS03520 (LVJ70_03515) 760442..760687 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
LVJ70_RS03525 (LVJ70_03520) 760797..761234 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
LVJ70_RS03530 (LVJ70_03525) 761231..761485 - 255 WP_003911263.1 antitoxin VapB7 -
LVJ70_RS03535 (LVJ70_03530) 761599..763962 + 2364 WP_003898547.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T228854 WP_003403365.1 NZ_CP089775:c758829-758446 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T228854 NZ_CP124350:c32903-32754 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT228854 WP_003403368.1 NZ_CP089775:c759079-758924 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT228854 NZ_CP124350:32947-33008 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References