Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 715711..716336 Replicon chromosome
Accession NZ_CP089775
Organism Mycobacterium tuberculosis strain 02-R1708

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag LVJ70_RS03280 Protein ID WP_003403218.1
Coordinates 715935..716336 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag LVJ70_RS03275 Protein ID WP_003403213.1
Coordinates 715711..715938 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ70_RS03250 (LVJ70_03245) 710890..711111 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LVJ70_RS03255 (LVJ70_03250) 711253..711858 + 606 WP_003898526.1 hypothetical protein -
LVJ70_RS03260 (LVJ70_03255) 711877..714444 - 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
LVJ70_RS03265 (LVJ70_03260) 714528..715277 + 750 WP_003898528.1 hypothetical protein -
LVJ70_RS03270 (LVJ70_03265) 715274..715516 + 243 WP_003403210.1 hypothetical protein -
LVJ70_RS03275 (LVJ70_03270) 715711..715938 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
LVJ70_RS03280 (LVJ70_03275) 715935..716336 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
LVJ70_RS03285 (LVJ70_03280) 716465..716548 + 84 Protein_651 galactose-1-phosphate uridylyltransferase -
LVJ70_RS03290 (LVJ70_03285) 716567..717648 + 1082 Protein_652 galactose-1-phosphate uridylyltransferase -
LVJ70_RS03295 (LVJ70_03290) 717645..718736 + 1092 WP_003906403.1 galactokinase -
LVJ70_RS03300 (LVJ70_03295) 719131..720195 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
LVJ70_RS03305 (LVJ70_03300) 720299..721246 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T228851 WP_003403218.1 NZ_CP089775:715935-716336 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T228851 NZ_CP124349:c4331861-4331643 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT228851 WP_003403213.1 NZ_CP089775:715711-715938 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT228851 NZ_CP124349:c4332261-4331887 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References