Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 325976..326604 Replicon chromosome
Accession NC_010718
Organism Natranaerobius thermophilus JW/NM-WN-LF

Toxin (Protein)


Gene name mazF Uniprot ID B2A573
Locus tag NTHER_RS01700 Protein ID WP_012446795.1
Coordinates 326254..326604 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NTHER_RS01695 Protein ID WP_012446794.1
Coordinates 325976..326248 (+) Length 91 a.a.

Genomic Context

NTHER_RS01675NTHER_RS01680NTHER_RS01685NTHER_RS01690NTHER_RS01695NTHER_RS01700NTHER_RS01705NTHER_RS01710NTHER_RS01715NTHER_RS01720NTHER_RS01725
Location: 321285..322886 (1602 bp)
Type: Others
Protein ID: WP_012446790.1
Location: 322952..323395 (444 bp)
Type: Others
Protein ID: WP_012446791.1
Location: 323463..324488 (1026 bp)
Type: Others
Protein ID: WP_158438188.1
Location: 324660..325832 (1173 bp)
Type: Others
Protein ID: WP_012446793.1
Location: 325976..326248 (273 bp)
Type: Antitoxin
Protein ID: WP_012446794.1
Location: 326254..326604 (351 bp)
Type: Toxin
Protein ID: WP_012446795.1
Location: 326660..327667 (1008 bp)
Type: Others
Protein ID: WP_012446796.1
Location: 327700..328704 (1005 bp)
Type: Others
Protein ID: WP_012446797.1
Location: 328751..329566 (816 bp)
Type: Others
Protein ID: WP_012446798.1
Location: 329673..330701 (1029 bp)
Type: Others
Protein ID: WP_012446799.1
Location: 330821..331453 (633 bp)
Type: Others
Protein ID: WP_012446800.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NTHER_RS01675321285..322886+1602WP_012446790.1bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase-
NTHER_RS01680322952..323395+444WP_012446791.1CBS domain-containing protein-
NTHER_RS01685323463..324488+1026WP_158438188.1hypothetical protein-
NTHER_RS01690324660..325832+1173WP_012446793.1alanine racemase-
NTHER_RS01695325976..326248+273WP_012446794.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
NTHER_RS01700326254..326604+351WP_012446795.1type II toxin-antitoxin system PemK/MazF family toxinToxin
NTHER_RS01705326660..327667+1008WP_012446796.1D-cysteine desulfhydrase family protein-
NTHER_RS01710327700..328704+1005WP_012446797.1asparaginase-
NTHER_RS01715328751..329566+816WP_012446798.1M55 family metallopeptidase-
NTHER_RS01720329673..330701+1029WP_012446799.1M42 family metallopeptidase-
NTHER_RS01725330821..331453-633WP_012446800.1protein-L-isoaspartate(D-aspartate) O-methyltransferase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-44)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12972.02 Da        Isoelectric Point: 7.2009

>T22885 WP_012446795.1 NC_010718:326254-326604 [Natranaerobius thermophilus JW/NM-WN-LF]
VNIKRGDIYYADLSPVIGSEQGGVRPVLVVQNDIGNKYSPTVIVVAITSQIQKAKLPTHVEITAEDYNLDKNSVVLTEQL
RTIDKQRLKEKITHIDKELMNKISEAIKISLGLIEF

Download         Length: 351 bp

>T22885 NC_010718:326254-326604 [Natranaerobius thermophilus JW/NM-WN-LF]
GTGAATATAAAACGTGGAGATATATATTATGCAGACCTAAGCCCTGTGATCGGTTCAGAACAGGGTGGAGTCAGACCAGT
TTTAGTAGTACAAAATGATATCGGTAACAAGTACAGCCCCACTGTAATCGTAGTAGCAATCACTTCTCAAATTCAAAAAG
CTAAACTTCCGACCCATGTAGAAATAACCGCTGAAGATTATAATTTAGATAAAAATTCAGTTGTATTGACTGAACAACTT
CGCACAATCGATAAACAGCGGTTAAAAGAAAAAATCACCCATATTGATAAAGAATTAATGAATAAAATAAGTGAAGCAAT
TAAGATCAGTCTTGGATTAATAGAATTCTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10474.87 Da        Isoelectric Point: 4.4301

>AT22885 WP_012446794.1 NC_010718:325976-326248 [Natranaerobius thermophilus JW/NM-WN-LF]
MSKTERIMISLPENLLEEIDGIVSNEQCSRSEFVRKAMRLYIEERRKREIRERMQKGYQEMASINLEIANEALEAENEAN
QLAEDIVSGV

Download         Length: 273 bp

>AT22885 NC_010718:325976-326248 [Natranaerobius thermophilus JW/NM-WN-LF]
TTGTCAAAAACGGAAAGAATTATGATAAGTTTACCAGAAAATCTACTAGAAGAGATCGACGGTATTGTTTCTAATGAACA
ATGCAGTCGAAGTGAATTTGTCAGAAAAGCTATGCGCTTGTATATAGAGGAGAGGAGAAAAAGAGAAATTCGTGAGAGGA
TGCAAAAGGGTTATCAAGAGATGGCCTCAATCAATTTGGAGATAGCTAATGAAGCACTGGAGGCTGAGAATGAAGCTAAT
CAATTAGCAGAAGATATAGTTAGTGGAGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBB2A573

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References