Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Txe-YefM |
| Location | 3769096..3769625 | Replicon | chromosome |
| Accession | NZ_CP089774 | ||
| Organism | Mycobacterium tuberculosis strain 02-R0894 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TI95 |
| Locus tag | LVJ69_RS17750 | Protein ID | WP_003417760.1 |
| Coordinates | 3769368..3769625 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0TI94 |
| Locus tag | LVJ69_RS17745 | Protein ID | WP_003417757.1 |
| Coordinates | 3769096..3769371 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ69_RS17710 (LVJ69_17710) | 3765669..3766358 | - | 690 | WP_003917774.1 | BBE domain-containing protein | - |
| LVJ69_RS17715 (LVJ69_17715) | 3766545..3766916 | - | 372 | WP_003417739.1 | FAD-binding protein | - |
| LVJ69_RS17720 (LVJ69_17720) | 3766814..3767032 | - | 219 | WP_157132559.1 | hypothetical protein | - |
| LVJ69_RS17725 (LVJ69_17725) | 3767059..3767319 | - | 261 | WP_003417741.1 | hypothetical protein | - |
| LVJ69_RS17730 (LVJ69_17730) | 3767434..3767823 | + | 390 | WP_003417745.1 | DUF732 domain-containing protein | - |
| LVJ69_RS17735 (LVJ69_17735) | 3767837..3768130 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
| LVJ69_RS17740 (LVJ69_17740) | 3768127..3768972 | - | 846 | WP_003417751.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
| LVJ69_RS17745 (LVJ69_17745) | 3769096..3769371 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
| LVJ69_RS17750 (LVJ69_17750) | 3769368..3769625 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
| LVJ69_RS17755 (LVJ69_17755) | 3769667..3770857 | + | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
| LVJ69_RS17760 (LVJ69_17760) | 3770974..3771342 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
| LVJ69_RS17765 (LVJ69_17765) | 3771339..3771890 | - | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
| LVJ69_RS17770 (LVJ69_17770) | 3771897..3772478 | - | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
| LVJ69_RS17775 (LVJ69_17775) | 3772459..3772827 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
| LVJ69_RS17780 (LVJ69_17780) | 3772805..3773197 | - | 393 | WP_003417776.1 | serine protease inhibitor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T228838 WP_003417760.1 NZ_CP089774:3769368-3769625 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T228838 NZ_CP124349:c2201091-2200777 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT228838 WP_003417757.1 NZ_CP089774:3769096-3769371 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT228838 NZ_CP124349:c2200780-2200364 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|