Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3702397..3703071 Replicon chromosome
Accession NZ_CP089774
Organism Mycobacterium tuberculosis strain 02-R0894

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag LVJ69_RS17520 Protein ID WP_003417282.1
Coordinates 3702397..3702825 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag LVJ69_RS17525 Protein ID WP_003417286.1
Coordinates 3702829..3703071 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ69_RS17495 (LVJ69_17495) 3698219..3698620 - 402 WP_003417264.1 cytidine deaminase -
LVJ69_RS17500 (LVJ69_17500) 3698857..3699195 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
LVJ69_RS17505 (LVJ69_17505) 3699192..3699626 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
LVJ69_RS17510 (LVJ69_17510) 3699755..3701527 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
LVJ69_RS17515 (LVJ69_17515) 3701527..3702318 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
LVJ69_RS17520 (LVJ69_17520) 3702397..3702825 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ69_RS17525 (LVJ69_17525) 3702829..3703071 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
LVJ69_RS17530 (LVJ69_17530) 3703193..3703807 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
LVJ69_RS17535 (LVJ69_17535) 3703804..3704094 - 291 Protein_3463 molybdenum cofactor biosynthesis protein MoaE -
LVJ69_RS17545 (LVJ69_17545) 3705447..3705827 - 381 Protein_3465 molybdopterin converting factor subunit 1 -
LVJ69_RS17550 (LVJ69_17550) 3705828..3706361 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
LVJ69_RS17555 (LVJ69_17555) 3706358..3706732 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
LVJ69_RS17560 (LVJ69_17560) 3706829..3707965 - 1137 WP_003417297.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T228837 WP_003417282.1 NZ_CP089774:c3702825-3702397 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T228837 NZ_CP124349:2035487-2035864 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT228837 WP_003417286.1 NZ_CP089774:c3703071-3702829 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT228837 NZ_CP124349:2035030-2035398 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References