Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2926075..2926789 Replicon chromosome
Accession NZ_CP089774
Organism Mycobacterium tuberculosis strain 02-R0894

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag LVJ69_RS13740 Protein ID WP_003413460.1
Coordinates 2926349..2926789 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag LVJ69_RS13735 Protein ID WP_003413456.1
Coordinates 2926075..2926362 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ69_RS13700 (LVJ69_13700) 2921497..2921742 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LVJ69_RS13705 (LVJ69_13705) 2921739..2922143 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
LVJ69_RS13710 (LVJ69_13710) 2922360..2922980 + 621 WP_003413441.1 DUF4178 domain-containing protein -
LVJ69_RS13715 (LVJ69_13715) 2922991..2923485 + 495 WP_003413444.1 DUF2617 family protein -
LVJ69_RS13720 (LVJ69_13720) 2923482..2923913 + 432 WP_003899390.1 DUF4247 domain-containing protein -
LVJ69_RS13725 (LVJ69_13725) 2923938..2924396 + 459 WP_003413451.1 DUF350 domain-containing protein -
LVJ69_RS13730 (LVJ69_13730) 2924393..2925964 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
LVJ69_RS13735 (LVJ69_13735) 2926075..2926362 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
LVJ69_RS13740 (LVJ69_13740) 2926349..2926789 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ69_RS13745 (LVJ69_13745) 2926810..2927565 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
LVJ69_RS13750 (LVJ69_13750) 2927698..2928294 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
LVJ69_RS13755 (LVJ69_13755) 2928302..2929147 - 846 WP_003413466.1 acyl-CoA thioesterase II -
LVJ69_RS13760 (LVJ69_13760) 2929176..2930075 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
LVJ69_RS13765 (LVJ69_13765) 2930203..2930877 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T228827 WP_003413460.1 NZ_CP089774:2926349-2926789 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T228827 NZ_CP124347:c4225371-4224994 [Escherichia coli]
ATGAAAACATTACCTGATACACACGTACGGAAGGTATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT228827 WP_003413456.1 NZ_CP089774:2926075-2926362 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT228827 NZ_CP124347:c4225828-4225460 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTTTTTATCCAACATCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References