Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2402944..2403473 Replicon chromosome
Accession NZ_CP089774
Organism Mycobacterium tuberculosis strain 02-R0894

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag LVJ69_RS11280 Protein ID WP_003411124.1
Coordinates 2402944..2403261 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag LVJ69_RS11285 Protein ID WP_003411127.1
Coordinates 2403258..2403473 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ69_RS11250 (LVJ69_11260) 2397965..2399041 + 1077 WP_003411110.1 hypothetical protein -
LVJ69_RS11255 (LVJ69_11265) 2399038..2399319 + 282 WP_003411112.1 DUF5703 family protein -
LVJ69_RS11260 (LVJ69_11270) 2399355..2400428 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
LVJ69_RS11265 (LVJ69_11275) 2400433..2400963 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
LVJ69_RS11270 (LVJ69_11280) 2401011..2402357 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
LVJ69_RS11280 (LVJ69_11290) 2402944..2403261 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ69_RS11285 (LVJ69_11295) 2403258..2403473 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
LVJ69_RS11290 (LVJ69_11300) 2403728..2404786 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
LVJ69_RS11295 (LVJ69_11305) 2404916..2405272 - 357 WP_003411130.1 hypothetical protein -
LVJ69_RS11300 (LVJ69_11310) 2405367..2406149 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
LVJ69_RS11305 (LVJ69_11315) 2406417..2406707 - 291 WP_003900476.1 YggT family protein -
LVJ69_RS11310 (LVJ69_11320) 2406869..2407525 - 657 WP_015456354.1 cell division protein SepF -
LVJ69_RS11315 (LVJ69_11325) 2407591..2408367 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T228821 WP_003411124.1 NZ_CP089774:c2403261-2402944 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T228821 NZ_CP124347:2963283-2963561 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT228821 WP_003411127.1 NZ_CP089774:c2403473-2403258 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT228821 NZ_CP124347:2963090-2963281 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGTAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References