Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2366023..2366718 Replicon chromosome
Accession NZ_CP089774
Organism Mycobacterium tuberculosis strain 02-R0894

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag LVJ69_RS11070 Protein ID WP_003410811.1
Coordinates 2366023..2366457 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag LVJ69_RS11075 Protein ID WP_003410814.1
Coordinates 2366464..2366718 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ69_RS11055 (LVJ69_11065) 2362212..2363750 + 1539 WP_023637436.1 HNH endonuclease signature motif containing protein -
LVJ69_RS11060 (LVJ69_11070) 2363949..2365619 + 1671 Protein_2187 SNF2 helicase-associated domain-containing protein -
LVJ69_RS11065 (LVJ69_11075) 2365622..2366044 + 423 Protein_2188 SWIM zinc finger family protein -
LVJ69_RS11070 (LVJ69_11080) 2366023..2366457 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ69_RS11075 (LVJ69_11085) 2366464..2366718 - 255 WP_003410814.1 antitoxin Antitoxin
LVJ69_RS11080 (LVJ69_11090) 2366734..2366991 - 258 WP_003410816.1 hypothetical protein -
LVJ69_RS11085 (LVJ69_11095) 2367938..2368234 + 297 WP_003410820.1 PE family protein -
LVJ69_RS11090 (LVJ69_11100) 2368290..2369021 + 732 WP_003900467.1 PPE family protein -
LVJ69_RS11095 (LVJ69_11105) 2369561..2370307 - 747 WP_003899174.1 proteasome subunit alpha -
LVJ69_RS11100 (LVJ69_11110) 2370304..2371179 - 876 WP_003411023.1 proteasome subunit beta -
LVJ69_RS11105 (LVJ69_11115) 2371176..2371370 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T228820 WP_003410811.1 NZ_CP089774:c2366457-2366023 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T228820 NZ_CP124347:2799748-2799855 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT228820 WP_003410814.1 NZ_CP089774:c2366718-2366464 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT228820 NZ_CP124347:c2799691-2799636 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References