Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1942138..1942751 Replicon chromosome
Accession NZ_CP089774
Organism Mycobacterium tuberculosis strain 02-R0894

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag LVJ69_RS09080 Protein ID WP_003408465.1
Coordinates 1942138..1942527 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag LVJ69_RS09085 Protein ID WP_003408469.1
Coordinates 1942524..1942751 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ69_RS09045 (LVJ69_09050) 1937767..1938681 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
LVJ69_RS09050 (LVJ69_09055) 1938684..1939514 + 831 WP_003408448.1 cyclase family protein -
LVJ69_RS09055 (LVJ69_09060) 1939514..1939864 + 351 WP_003898986.1 cupin domain-containing protein -
LVJ69_RS09060 (LVJ69_09065) 1939917..1940735 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
LVJ69_RS09065 (LVJ69_09070) 1940749..1941528 + 780 WP_003408460.1 IclR family transcriptional regulator -
LVJ69_RS09075 (LVJ69_09080) 1941959..1942090 + 132 Protein_1790 IS3 family transposase -
LVJ69_RS09080 (LVJ69_09085) 1942138..1942527 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ69_RS09085 (LVJ69_09090) 1942524..1942751 - 228 WP_003408469.1 antitoxin Antitoxin
LVJ69_RS09090 (LVJ69_09095) 1942969..1944453 + 1485 WP_003408473.1 biotin carboxylase -
LVJ69_RS09095 (LVJ69_09100) 1944450..1945697 + 1248 WP_003408476.1 serine hydrolase -
LVJ69_RS09100 (LVJ69_09105) 1945740..1946159 - 420 WP_003408483.1 hypothetical protein -
LVJ69_RS09105 (LVJ69_09110) 1946149..1946859 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T228809 WP_003408465.1 NZ_CP089774:c1942527-1942138 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T228809 NZ_CP124347:188541-188648 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT228809 WP_003408469.1 NZ_CP089774:c1942751-1942524 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT228809 NZ_CP124347:c188484-188427 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References