Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1578202..1578857 Replicon chromosome
Accession NZ_CP089774
Organism Mycobacterium tuberculosis strain 02-R0894

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag LVJ69_RS07485 Protein ID WP_003898861.1
Coordinates 1578202..1578603 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag LVJ69_RS07490 Protein ID WP_003407272.1
Coordinates 1578600..1578857 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ69_RS07470 (LVJ69_07470) 1573675..1575060 - 1386 WP_003407260.1 cytochrome P450 -
LVJ69_RS07475 (LVJ69_07475) 1575138..1576172 + 1035 WP_003407264.1 AraC family transcriptional regulator -
LVJ69_RS07480 (LVJ69_07480) 1576218..1577947 - 1730 Protein_1473 PE family protein -
LVJ69_RS07485 (LVJ69_07485) 1578202..1578603 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ69_RS07490 (LVJ69_07490) 1578600..1578857 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
LVJ69_RS07495 (LVJ69_07495) 1578940..1579899 - 960 WP_003407276.1 alpha/beta hydrolase -
LVJ69_RS07500 (LVJ69_07500) 1579924..1580886 - 963 WP_003407279.1 alpha/beta hydrolase -
LVJ69_RS07505 (LVJ69_07505) 1580885..1581622 + 738 WP_031647000.1 lysoplasmalogenase -
LVJ69_RS07510 (LVJ69_07510) 1581703..1583670 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T228806 WP_003898861.1 NZ_CP089774:c1578603-1578202 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T228806 NZ_CP124345:c4550444-4550271 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT228806 WP_003407272.1 NZ_CP089774:c1578857-1578600 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT228806 NZ_CP124345:c4550768-4550472 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCCGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References