Detailed information of TA system TA022880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1509357..1510542
• Replicon: chromosome
• Accession: NC_010698
• Organism: Helicobacter pylori Shi470

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: HPSH_RS07330
• Protein ID: WP_000448212.1
• Coordinates: 1509357..1510115 (-)
• Length: 253 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: HPSH_RS07335
• Protein ID: WP_000248393.1
• Coordinates: 1510105..1510542 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPSH_RS07320	1506690..1507850	+	1161	WP_001051182.1	L-seryl-tRNA(Sec) selenium transferase	-
HPSH_RS07325	1507938..1509125	+	1188	WP_000411641.1	transcription termination/antitermination protein NusA	-
HPSH_RS07330	1509357..1510115	-	759	WP_000448212.1	hypothetical protein	Toxin
HPSH_RS07335	1510105..1510542	-	438	WP_000248393.1	SocA family protein	Antitoxin
HPSH_RS07340	1510751..1512376	-	1626	WP_041199660.1	RNA-directed DNA polymerase	-
HPSH_RS07345	1512387..1512911	-	525	WP_000413001.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 253 a.a.
• Molecular weight: 29589.64 Da
• Isoelectric Point: 7.8450

>T22880 WP_000448212.1 NC_010698:c1510115-1509357 [Helicobacter pylori Shi470]
METKEENKDKKLEEIIVLLCEEGDLSSQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKALKEIQ
NNREVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFVG
GLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEEKDKQENFKKPIFWFNLMVTILFMIGFFGE
LHIIQRLVSKYL

Nucleotide

• Length: 759 bp

>T22880 NC_010698:c1510115-1509357 [Helicobacter pylori Shi470]
ATGGAAACTAAAGAAGAGAATAAAGATAAAAAGCTAGAAGAAATTATTGTATTGCTGTGCGAAGAGGGGGATTTGTCTAG
TCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGGCACTCAAAGAGATTCAA
AATAATAGAGAAGTTGAAAGTATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAGATGATCTAAATAAAAACTATAAAAAATTAA
GCGAAGAATTGAATAAGCAACAAACACAATACATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTTGGG
GGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTTTAT
AGCTTTATTTTTTGGGAATATTTTGTATCTACTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGGAAAAAGATA
AACAAGAAAATTTCAAAAAACCTATTTTTTGGTTTAATCTAATGGTTACAATTCTATTTATGATTGGTTTTTTTGGAGAA
TTGCATATAATACAAAGATTAGTTTCTAAATATCTTTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17280.38 Da
• Isoelectric Point: 6.3468

>AT22880 WP_000248393.1 NC_010698:c1510542-1510105 [Helicobacter pylori Shi470]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINHSIKKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT22880 NC_010698:c1510542-1510105 [Helicobacter pylori Shi470]
ATGGTCAATACTTTGGAACTAGCAAAATATATTCTTAAGCATTCAAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGACAAGCACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTGCAAGAGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCTATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAGAAGATGAACTTGAAACCATCAATCACTCCATAAAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGCGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAGGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCAAATGGAAACTAA