Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 846337..847046 Replicon chromosome
Accession NZ_CP089774
Organism Mycobacterium tuberculosis strain 02-R0894

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag LVJ69_RS04005 Protein ID WP_003403837.1
Coordinates 846618..847046 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag LVJ69_RS04000 Protein ID WP_003403834.1
Coordinates 846337..846594 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ69_RS03995 (LVJ69_03990) 844021..846246 + 2226 WP_031649607.1 PE family protein -
LVJ69_RS04000 (LVJ69_03995) 846337..846594 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
LVJ69_RS04005 (LVJ69_04000) 846618..847046 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ69_RS04010 (LVJ69_04005) 847127..847264 - 138 WP_003403839.1 hypothetical protein -
LVJ69_RS04015 (LVJ69_04015) 847423..847668 + 246 WP_003403841.1 hypothetical protein -
LVJ69_RS04020 (LVJ69_04020) 847737..848621 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
LVJ69_RS04025 (LVJ69_04025) 848632..849804 - 1173 WP_003403845.1 acyl-CoA dehydrogenase family protein -
LVJ69_RS04030 (LVJ69_04030) 849811..851343 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T228797 WP_003403837.1 NZ_CP089774:846618-847046 [Mycobacterium tuberculosis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T228797 NZ_CP124345:2801297-2801404 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT228797 WP_003403834.1 NZ_CP089774:846337-846594 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT228797 NZ_CP124345:c2801240-2801185 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References