Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 715712..716337 Replicon chromosome
Accession NZ_CP089774
Organism Mycobacterium tuberculosis strain 02-R0894

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag LVJ69_RS03280 Protein ID WP_003403218.1
Coordinates 715936..716337 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag LVJ69_RS03275 Protein ID WP_003403213.1
Coordinates 715712..715939 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ69_RS03250 (LVJ69_03245) 710891..711112 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LVJ69_RS03255 (LVJ69_03250) 711254..711859 + 606 WP_003898526.1 hypothetical protein -
LVJ69_RS03260 (LVJ69_03255) 711878..714445 - 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
LVJ69_RS03265 (LVJ69_03260) 714529..715278 + 750 WP_003898528.1 hypothetical protein -
LVJ69_RS03270 (LVJ69_03265) 715275..715517 + 243 WP_003403210.1 hypothetical protein -
LVJ69_RS03275 (LVJ69_03270) 715712..715939 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
LVJ69_RS03280 (LVJ69_03275) 715936..716337 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
LVJ69_RS03285 (LVJ69_03280) 716466..716549 + 84 Protein_651 galactose-1-phosphate uridylyltransferase -
LVJ69_RS03290 (LVJ69_03285) 716568..717649 + 1082 Protein_652 galactose-1-phosphate uridylyltransferase -
LVJ69_RS03295 (LVJ69_03290) 717646..718737 + 1092 WP_003906403.1 galactokinase -
LVJ69_RS03300 (LVJ69_03295) 719132..720196 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
LVJ69_RS03305 (LVJ69_03300) 720300..721247 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T228790 WP_003403218.1 NZ_CP089774:715936-716337 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T228790 NZ_CP124345:c827241-826864 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAAAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT228790 WP_003403213.1 NZ_CP089774:715712-715939 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT228790 NZ_CP124345:c827698-827318 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAACAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References