Detailed information of TA system TA022879

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 928847..929471
• Replicon: chromosome
• Accession: NC_010698
• Organism: Helicobacter pylori Shi470

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPSH_RS04465
• Protein ID: WP_000916174.1
• Coordinates: 928847..929113 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPSH_RS04470
• Protein ID: WP_001133851.1
• Coordinates: 929094..929471 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPSH_RS04445	925497..926264	-	768	WP_000242365.1	ABC transporter ATP-binding protein	-
HPSH_RS04450	926264..927244	-	981	WP_000921443.1	iron ABC transporter permease	-
HPSH_RS04455	927237..928079	-	843	WP_000504115.1	SDR family oxidoreductase	-
HPSH_RS04460	928220..928744	+	525	WP_001120217.1	acyl-CoA thioesterase	-
HPSH_RS04465	928847..929113	-	267	WP_000916174.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPSH_RS04470	929094..929471	-	378	WP_001133851.1	hypothetical protein	Antitoxin
HPSH_RS04475	929699..931930	-	2232	WP_000716208.1	outer membrane beta-barrel protein	-
HPSH_RS04490	932269..932897	+	629	Protein_864	hypothetical protein	-
HPSH_RS04495	932848..933960	-	1113	WP_000115670.1	hydrogenase formation protein HypD	-
HPSH_RS04500	933979..934215	-	237	WP_000335458.1	HypC/HybG/HupF family hydrogenase formation chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10346.20 Da
• Isoelectric Point: 9.9510

>T22879 WP_000916174.1 NC_010698:c929113-928847 [Helicobacter pylori Shi470]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFKDHALKGNWKPFRECHIKADILLVYLVKDDELILLR
LGSHSERF

Nucleotide

• Length: 267 bp

>T22879 NC_010698:c929113-928847 [Helicobacter pylori Shi470]
GTGTTAAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAACAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCACAATTTAAAGATCATGCTTTAAAAGGCAATTGGA
AGCCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTCATTTTGTTAAGA
CTAGGCAGTCATAGCGAGCGGTTTTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14657.64 Da
• Isoelectric Point: 8.7066

>AT22879 WP_001133851.1 NC_010698:c929471-929094 [Helicobacter pylori Shi470]
MPNSPTKKDCTQYSEKQLFNLINQLERKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFNNKRDCCL
GHEIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVKTQS

Nucleotide

• Length: 378 bp

>AT22879 NC_010698:c929471-929094 [Helicobacter pylori Shi470]
ATGCCTAACTCTCCCACCAAAAAAGACTGCACGCAATACAGCGAAAAACAGCTTTTTAATTTAATCAATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTAATAATAAAAGAGATTGTTGTTTG
GGGCATGAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCACTCAACAAAGAAACCGATTTGATTGTTGAAGA
TTTTTCTAGTTATAGCGATGAGAGAAAAAGGGCTTTGGGTGTTAAAACTCAATCTTAA