Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 708174..708817 Replicon chromosome
Accession NZ_CP089774
Organism Mycobacterium tuberculosis strain 02-R0894

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag LVJ69_RS03230 Protein ID WP_003403187.1
Coordinates 708416..708817 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag LVJ69_RS03225 Protein ID WP_003403184.1
Coordinates 708174..708419 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ69_RS03190 (LVJ69_03185) 703454..703984 - 531 WP_003917320.1 two component system sensor kinase HK2 -
LVJ69_RS03195 (LVJ69_03190) 703968..704663 - 696 WP_003918099.1 two-component system response regulator TcrA -
LVJ69_RS03200 (LVJ69_03195) 704786..705097 + 312 WP_003403164.1 hypothetical protein -
LVJ69_RS03205 (LVJ69_03200) 705169..706119 + 951 WP_003900184.1 DUF1259 domain-containing protein -
LVJ69_RS03210 (LVJ69_03205) 706360..706944 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
LVJ69_RS03215 (LVJ69_03210) 706946..707656 + 711 Protein_637 IS607 family element RNA-guided endonuclease TnpB -
LVJ69_RS03220 (LVJ69_03215) 707659..708129 + 471 WP_003898523.1 hypothetical protein -
LVJ69_RS03225 (LVJ69_03220) 708174..708419 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ69_RS03230 (LVJ69_03225) 708416..708817 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ69_RS03235 (LVJ69_03230) 708808..708987 + 180 Protein_641 hypothetical protein -
LVJ69_RS03240 (LVJ69_03235) 709405..709602 - 198 WP_003403191.1 hypothetical protein -
LVJ69_RS03245 (LVJ69_03240) 709682..710839 - 1158 WP_003898524.1 hypothetical protein -
LVJ69_RS03250 (LVJ69_03245) 710891..711112 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LVJ69_RS03255 (LVJ69_03250) 711254..711859 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T228789 WP_003403187.1 NZ_CP089774:708416-708817 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T228789 NZ_CP124345:645572-645886 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT228789 WP_003403184.1 NZ_CP089774:708174-708419 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT228789 NZ_CP124345:645883-646299 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References