Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 447823..448834 Replicon chromosome
Accession NZ_CP089774
Organism Mycobacterium tuberculosis strain 02-R0894

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag LVJ69_RS01955 Protein ID WP_003401859.1
Coordinates 447823..448416 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag LVJ69_RS01960 Protein ID WP_003401860.1
Coordinates 448445..448834 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ69_RS01935 (LVJ69_01935) 443472..444854 + 1383 WP_003898415.1 magnesium transporter -
LVJ69_RS01940 (LVJ69_01940) 444866..445900 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
LVJ69_RS01945 (LVJ69_01945) 445996..446679 + 684 WP_003401857.1 VTT domain-containing protein -
LVJ69_RS01950 (LVJ69_01950) 446668..447798 - 1131 WP_003900130.1 glycoside hydrolase family 76 protein -
LVJ69_RS01955 (LVJ69_01955) 447823..448416 - 594 WP_003401859.1 zeta toxin family protein Toxin
LVJ69_RS01960 (LVJ69_01960) 448445..448834 - 390 WP_003401860.1 hypothetical protein Antitoxin
LVJ69_RS01965 (LVJ69_01965) 448915..450126 - 1212 WP_003900131.1 VWA domain-containing protein -
LVJ69_RS01970 (LVJ69_01970) 450132..450734 - 603 WP_003898417.1 SRPBCC family protein -
LVJ69_RS01975 (LVJ69_01975) 450748..451644 - 897 WP_003898418.1 MoxR family ATPase -
LVJ69_RS01980 (LVJ69_01980) 451641..452234 - 594 WP_003401864.1 NTP transferase domain-containing protein -
LVJ69_RS01985 (LVJ69_01985) 452231..452986 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T228784 WP_003401859.1 NZ_CP089774:c448416-447823 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T228784 NZ_CP124344:c142272-141967 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT228784 WP_003401860.1 NZ_CP089774:c448834-448445 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT228784 NZ_CP124344:c142492-142274 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References